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首页> 外文期刊>RGUHS Journal of Pharmaceutical Sciences >Method development and validation for the estimation of famotidine in pure and tablet dosage form by derivative spectroscopy and uv-spectroscopy
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Method development and validation for the estimation of famotidine in pure and tablet dosage form by derivative spectroscopy and uv-spectroscopy

机译：通过导数光谱和紫外光谱法估算纯和片剂剂型中法莫替丁的方法开发和验证

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Two simple, precise, rapid, sensitive and accurate spectrophotometric methods have been developed for the estimation of famotidine in pure and in tablet dosage form. Method A: famotidine showed an absorbance maxima at 266 nm in methanol: water (80:20 V/V) for UV spectroscopy; the linearity was found to be in the concentration range of 4 - 20 μg/ml, correlation coefficient were 0.9993, the precision values were 0.32–1.38 with mean accuracy value 100.18–103.39 %, limit of detection 0.22 and limit of quantification 0.67. Method B: famotidine showed an absorbance minima at 254 nmin methanol: water (80:20 V/V) for first order derivative spectroscopy; the linearity was found to be in the concentration range of 4 - 20 μg/ml, correlation coefficient were 1.0, the precision values were 1.05–1.18 with mean accuracy value 97.33–102.05 % respectively, limit of detection 0.66 and limit of quantification 2.0. Both the methods were validated as per the International Conference on Harmonization (ICH) guidelines. The validated methods can be used for the quantitative analysis of famotidine in pure form and in tablet dosage form.
机译：已经开发出两种简单，精确，快速，灵敏和准确的分光光度法来估算纯法莫替丁和片剂剂型中的法莫替丁。方法A：法莫替丁在甲醇：水（80:20 V / V）中显示266 nm的最大吸光度，用于紫外光谱;线性在4-20μg/ ml的浓度范围内，相关系数为0.9993，精密度值为0.32-1.38，平均准确度值为100.18-103.39％，检测限为0.22，定量限为0.67。方法B：法莫替丁在甲醇：水（80:20 V / V）中的254 nm处显示最小吸光度，用于一阶导数光谱;线性范围为4-20μg/ ml，相关系数为1.0，精密度值为1.05-1.18，平均准确度值为97.33-102.05％，检出限为0.66，定量限为2.0。两种方法均已根据国际协调会议（ICH）指南进行了验证。经验证的方法可用于法莫替丁纯形式和片剂剂型的定量分析。

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