• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Open access Insect Physiology >Characterization of AMPK in female Aedes aegypti and Georgecraigius atropalpus mosquitoes in relation to low and adequate food intake
【24h】

Characterization of AMPK in female Aedes aegypti and Georgecraigius atropalpus mosquitoes in relation to low and adequate food intake

机译：雌性埃及伊蚊和乔治·克雷修斯·阿特罗波利斯蚊中AMPK的特征与食物摄入量的低下和充分相关

获取原文
       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

AMPK is a sensor of cellular fuel and energy status in mammals and Drosophila melanogaster . When activated, AMPK switches off anabolic pathways that consume ATP and switches on catabolic processes that produce ATP. We investigated the role of AMPK in regulating energy metabolism in autogenous Georgecraigius atropalpus (formerly Ochlerotatus atropalpus ) and anautogenous Aedes aegypti L. ( Stegomyia aegypti ), mosquitoes that differ to varying degrees on larval and adult-derived nutrients for reproduction. We fed chemical activators of AMPK to mosquitoes to signal metabolic stress, and then measured macronutrients utilized in response and whether this response affected mosquito egg development. Our results demonstrate a role for AMPK in mosquito energy metabolism and we report that catabolic pathways affected by AMPK activation differ according to female nutritional condition and breeding strategy. Glycogen was the first source of energy utilized by well-nourished females in response to chronic AMPK activation. In malnourished females, the catabolic pathway activated depended on female breeding strategy. Lastly, we observed delayed follicle development in female Gc. atropalpus in which AMPK was chronically activated. Our results indicate that AMPK signaling of metabolic stress leads to a decrease in macronutrients that may affect mosquito reproduction. The AMPK regulatory pathway offers an attractive target for disruption as an approach for mosquito vector population control.
机译：AMPK是哺乳动物和黑果蝇（Drosophila melanogaster）中细胞燃料和能量状况的传感器。激活后，AMPK会关闭消耗ATP的合成代谢途径，并打开产生ATP的分解代谢过程。我们调查了AMPK在调节自体乔治克雷格托斯atropalpus（以前的Ochlerotatus atropalpus）和自体伊蚊Aegespti L.（Stegomyia aegypti）中的能量代谢中的作用，这些蚊子在幼虫和成年后的养分上都有不同程度的繁殖。我们向蚊子喂食了AMPK的化学激活剂，以发出新陈代谢的信号，然后测量了用于响应的大量营养素以及该响应是否影响了蚊卵的发育。我们的结果证明了AMPK在蚊子能量代谢中的作用，并且我们报道了受AMPK激活影响的分解代谢途径根据女性的营养状况和繁殖策略而有所不同。糖原是营养丰富的女性响应慢性AMPK激活而利用的第一能源。在营养不良的雌性中，分解代谢途径的激活取决于雌性的育种策略。最后，我们观察到女性Gc的卵泡发育延迟。 AMPK被长期激活的阿托品鼠。我们的结果表明，代谢应激的AMPK信号导致大量营养物质的减少，这可能会影响蚊子的繁殖。 AMPK调节途径作为控制蚊媒种群的方法，提供了一个有吸引力的破坏目标。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号