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首页> 外文期刊>Orthopaedic Journal of Sports Medicine >Effect of Oral Contraceptives on Soft Tissue Injury Risk, Soft Tissue Laxity, and Muscle Strength: A Systematic Review of the Literature
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Effect of Oral Contraceptives on Soft Tissue Injury Risk, Soft Tissue Laxity, and Muscle Strength: A Systematic Review of the Literature

机译：口服避孕药对软组织损伤风险，软组织松弛和肌肉力量的影响：系统评价文献

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Background: Female patients are more likely than male patients to experience various musculoskeletal (MSK) injuries. Because MSK tissues are sensitive to the female hormones relaxin, estrogen, and progesterone, studies have examined whether hormonal contraceptives, which change female hormone levels, can alter the female MSK injury risk. These studies have reached contradictory conclusions, leaving unclear the influence of hormonal contraception on female MSK injury risk. Hypothesis: Hormonal contraceptives act to decrease female soft tissue injury risk and soft tissue laxity. Study Design: Systematic review; Level of evidence, 3. Methods: Reviewers searched for clinically relevant studies evaluating the relationship between hormonal contraceptive use and soft tissue injuries, soft tissue laxity, muscle injuries, and muscle strength in the PubMed, Cochrane, Scopus, CINAHL, and Embase databases. Studies meeting inclusion criteria were scored by 2 independent researchers for risk of bias, imprecision, inconsistency, and indirectness with a template designed using the British Medical Journal Clinical Evidence GRADE (Grades of Recommendation Assessment, Development and Evaluation) scoring system and GRADEPro guidelines. Scores were uploaded into the GRADEPro scoring system software, which calculated each study’s final GRADE score ( very low , low , moderate , or high quality). Results: A total of 29 studies met inclusion criteria. Of the 7 studies evaluating oral contraceptive (OC) use and soft tissue injury risk, only 2 received a high quality-of-evidence score; all other studies received a very low score. The high-quality studies concluded that OC use decreases anterior cruciate ligament (ACL) injury risk. Only 1 of the 10 studies evaluating OC use and soft tissue laxity was found to have a high quality of evidence; this study determined that OC use decreases ACL laxity. Conclusion: Higher quality studies suggest that OCs decrease a female patient’s risk of ACL injuries and ACL laxity. The strength of these findings, however, is weak. Female patients are up to 8 times more likely to tear their ACLs than male patients. OCs may serve a therapeutic role in decreasing the sex disparity in ACL injury rates.
机译：背景：女性患者比男性患者更有可能遭受各种肌肉骨骼（MSK）损伤。由于MSK组织对女性激素松弛素，雌激素和孕激素敏感，因此研究检查了改变女性激素水平的激素避孕药是否可以改变女性MSK损伤的风险。这些研究得出了矛盾的结论，尚不清楚激素避孕对女性MSK损伤风险的影响。假设：激素避孕药可降低女性软组织损伤的风险和软组织松弛。研究设计：系统评价;证据等级，3。方法：评价者在PubMed，Cochrane，Scopus，CINAHL和Embase数据库中搜索临床相关研究，以评估激素避孕药使用与软组织损伤，软组织松弛，肌肉损伤和肌肉力量之间的关系。符合入选标准的研究由2位独立研究人员对偏倚，不精确，不一致和间接的风险进行评分，并使用英国医学杂志临床证据GRADE（推荐评估，开发和评估等级）评分系统和GRADEPro指南设计的模板进行评分。将分数上载到GRADEPro评分系统软件中，该软件可以计算每个研究的最终GRADE分数（非常低，低，中等或高质量）。结果：共有29项研究符合纳入标准。在评估口服避孕药（OC）使用和软组织损伤风险的7项研究中，只有2项的证据质量高;所有其他研究的得分都非常低。高质量的研究得出的结论是，使用OC可以降低前十字韧带（ACL）的受伤风险。在评估OC使用和软组织松弛的10项研究中，只有1项具有高质量的证据。这项研究确定使用OC可以降低ACL松弛。结论：更高质量的研究表明，OCs可以降低女性患者发生ACL损伤和ACL松弛的风险。然而，这些发现的力量很弱。女性患者撕开ACL的可能性是男性患者的8倍。 OC可能在减少ACL损伤率方面的性别差异方面起到治疗作用。

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