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首页> 外文期刊>Schizophrenia research and treatment >Clinical Practice Associated with a Switch from and to Ziprasidone during Routine Inpatient Treatment of Patients with Schizophrenia
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Clinical Practice Associated with a Switch from and to Ziprasidone during Routine Inpatient Treatment of Patients with Schizophrenia

机译：精神分裂症患者常规住院治疗期间与吉普西酮换药的临床实践

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Ziprasidone (ZIP) shows a low propensity for metabolic side effects but can prolong QTc time. It is unclear how these features translate into clinical reality. Charts of inpatients with schizophrenia and switched from (ZIP−,n=27) or to ZIP (ZIP+,n=24) were reviewed. Clinical data including documented switch reasons were anonymously analyzed. Comorbidity, body mass index (BMI) at admission, illness severity, side effects, illness duration, and length of stay were comparable in both groups. About 2/3 ofZIP+were women (1/3 ofZIP−,P=0.035);ZIP+patients were younger (P=0.017), had higher BMI values (P=0.042), and received higher chlorpromazine equivalents before switch (P=0.004) whereas ZIP doses were comparable (136 versus 141 mg/d). More patients inZIP−versusZIP+were switched because of previous weight gain (P=0.006) and depression (P=0.085) whereas single reasons forZIP−versusZIP+were mainly persisting positive symptoms (P=0.089) and patients' choice (P=0.10). The results of the naturalistic study corroborate controlled trials.
机译：Ziprasidone（ZIP）对代谢性副作用显示出较低的倾向，但可以延长QTc时间。尚不清楚这些功能如何转化为临床现实。回顾了精神分裂症住院患者的图表（从（ZIP-，n = 27）或改为ZIP（ZIP +，n = 24））。临床数据包括记录的转换原因被匿名分析。两组的合并症，入院时的体重指数（BMI），病情轻重，副作用，病程和住院时间在两组中相当。大约2/3的ZIP +是女性（ZIP-的1/3，P = 0.035）; ZIP +的患者较年轻（P = 0.017），BMI值较高（P = 0.042），换用前接受更高的氯丙嗪当量（P = 0.004），而ZIP剂量可比（136对141 mg / d）。由于先前的体重增加（P = 0.006）和抑郁症（P = 0.085），更多的ZIP-versusZIP +患者被切换，而ZIP-versusZIP +的单一原因主要是阳性症状（P = 0.089）和患者的选择（P = 0.10）。 ）。自然研究的结果证实了对照试验。

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