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首页> 外文期刊>Schizophrenia research and treatment >Relationships between Brain Structure and Metabolic Changes in Schizophrenia Patients Treated with Olanzapine: A Voxel-Based Morphometric Study
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Relationships between Brain Structure and Metabolic Changes in Schizophrenia Patients Treated with Olanzapine: A Voxel-Based Morphometric Study

机译：奥氮平治疗精神分裂症患者脑结构与代谢变化之间的关系：基于体素的形态计量学研究

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Introduction. Second-generation antipsychotics treatment is associated with weight gain and metabolic disturbances. Although much research has been done on the topic, the precise mechanisms underlying such side effects are still not well understood.Method. We followed over 16 weeks a group of 17 schizophrenia patients who were treated with olanzapine and monitored biometric, clinical, and metabolic data, including ghrelin and leptin levels. All patients had a structural cerebral magnetic resonance imaging examination during the first week of their followup and at the end of the study.Results. We found positive and negative significant correlations between grey matter volumes of several brain regions and variations of body weight as well as of ghrelin and leptin levels. The right frontal operculum, bilateral precuneus, and bilateral hippocampal regions were found to be significantly associated with those changes.Conclusion. Our results suggest associations between brain structure and metabolic variations in schizophrenia patients taking olanzapine.
机译：介绍。第二代抗精神病药物治疗与体重增加和代谢紊乱有关。尽管已对该主题进行了大量研究，但仍未很好地了解引起此类副作用的确切机制。我们随访了16周的17名精神分裂症患者，这些患者接受了奥氮平治疗并监测了生物特征，临床和代谢数据，包括生长素释放肽和瘦素水平。所有患者在随访的第一周和研究结束时均进行了结构性脑磁共振成像检查。我们发现几个大脑区域的灰质体积与体重以及生长素释放肽和瘦素水平的变化之间存在正相关和负相关。发现右额front，双前突和双侧海马区与这些变化显着相关。我们的结果表明服用奥氮平的精神分裂症患者的大脑结构与代谢变化之间存在关联。

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