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首页> 外文期刊>Sao Paulo Medical Journal >Canonical and noncanonical Wnt pathways: a comparison between endometrial cancer type I and atrophic endometrium in Brazil
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Canonical and noncanonical Wnt pathways: a comparison between endometrial cancer type I and atrophic endometrium in Brazil

机译：规范和非规范的Wnt途径：在巴西的I型子宫内膜癌与萎缩性子宫内膜之间的比较

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CONTEXT AND OBJECTIVE: The Wnt pathway is involved in tumorigenesis of several tissues. For this reason, we proposed to evaluate Wnt gene expression in endometrial cancer type I. DESIGN AND SETTING: Cross-sectional study on materials gathered from the tissue bank of the Department of Pathology, Universidade Federal de S?o Paulo. METHODS: Endometrial specimens were obtained from surgeries performed between 1995 and 2005 at S?o Paulo Hospital, Universidade Federal de S?o Paulo. The material was divided into two groups according to tissue type: Group A, atrophic endometrium (n = 15); and Group B, endometrial adenocarcinoma (n = 45). We compared the immunohistochemical expression of Wnt1, Frizzled-1 (FZD1), Wnt5a, Frizzled-5 (FZD5) and beta-catenin between endometrial cancer type I and atrophic endometrium. RESULTS: Regarding Wnt1, FZD1 and Wnt5a expression, no significant association was observed between the groups. A significant association was observed between the groups in relation to FZD5 expression (P = 0.001). The proportion of FZD5-positive samples was significantly higher in group A (80.0%) than in group B (31.1%). Regarding the survival curve for FZD5 in group B, we did not find any significant association between atrophic endometrium and endometrial adenocarcinoma. We also did not find any significant association regarding beta-catenin expression (P = 1.000). CONCLUSION: FZD5 is downregulated in endometrial adenocarcinoma, in comparison with atrophic endometrium
机译：背景与目的：Wnt通路参与了几种组织的肿瘤发生。因此，我们提议评估Wnt基因在I型子宫内膜癌中的表达。设计与环境：对从圣保罗联邦大学病理学系组织库收集的材料进行的横断面研究。方法：子宫内膜标本取自1995年至2005年在圣保罗联邦大学圣保罗医院进行的手术。根据组织类型将材料分为两组：A组，萎缩性子宫内膜（n = 15）; B组子宫内膜腺癌（n = 45）。我们比较了子宫内膜癌I型和萎缩性子宫内膜之间Wnt1，Frizzled-1（FZD1），Wnt5a，Frizzled-5（FZD5）和β-catenin的免疫组织化学表达。结果：关于Wnt1，FZD1和Wnt5a表达，没有观察到两组之间的显着关联。观察到两组之间与FZD5表达有显着相关性（P = 0.001）。 A组（80.0％）的FZD5阳性样本比例显着高于B组（31.1％）。关于B组中FZD5的生存曲线，我们在萎缩性子宫内膜和子宫内膜腺癌之间未发现任何显着相关性。我们也没有发现有关β-catenin表达的任何显着关联（P = 1.000）。结论：与萎缩性子宫内膜相比，FZD5在子宫内膜腺癌中被下调。

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