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首页> 外文期刊>Sao Paulo Medical Journal >Prevalence and clinical features of celiac disease in patients with autoimmune thyroiditis: cross-sectional study
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Prevalence and clinical features of celiac disease in patients with autoimmune thyroiditis: cross-sectional study

机译：自身免疫性甲状腺炎患者乳糜泻的患病率和临床特征：横断面研究

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CONTEXT AND OBJECTIVE: Celiac disease is an autoimmune disorder with an average prevalence of 1% in Europe and the United States. Because of strong European ancestry in southern Brazil, this study aimed to evaluate the seroprevalence of celiac disease among autoimmune thyroiditis patients.DESIGN AND SETTING: Cross-sectional study in a public university hospital.METHODS: This cross-sectional prevalence study included autoimmune thyroiditis patients who were tested for anti-endomysial and anti-transglutaminase antibodies between August 2010 and July 2011.RESULTS: Fifty-three patients with autoimmune thyroiditis were included; 92.5% were women, with mean age of 49.0 ± 13.5 years. Five patients (9.3%) were serologically positive for celiac disease: three of them (5.6%) were reactive for anti-endomysial antibodies and two (3.7%) for anti-transglutaminase. None of them exhibited anemia and one presented diarrhea. Endoscopy was performed on two patients: one with normal histology and the other with lymphocytic infiltrate and villous atrophy.CONCLUSION: The prevalence of celiac disease among patients with autoimmune thyroid disease was 9.3%; one patient complained of diarrhea and none presented anemia. Among at-risk populations, like autoimmune thyroiditis patients, the presence of diarrhea or anemia should not be used as a criterion for indicating celiac disease investigation. This must be done for all autoimmune thyroiditis patients because of its high prevalence.
机译：背景与目的：腹腔疾病是一种自身免疫性疾病，在欧洲和美国平均患病率为1％。由于在巴西南部有强大的欧洲血统，所以本研究旨在评估自身免疫性甲状腺炎患者的腹腔疾病的血清流行病学设计和设置：在一家公立大学医院进行的横断面研究方法：该横断面患病率研究包括自身免疫性甲状腺炎患者结果：在2010年8月至2011年7月之间进行了抗肌内膜和抗转谷氨酰胺酶抗体的检测。结果：纳入了53例自身免疫性甲状腺炎患者。女性占92.5％，平均年龄为49.0±13.5岁。五名患者（9.3％）的乳糜泻血清学阳性：其中三名（5.6％）的抗肌内膜抗体反应性，两名（3.7％）的抗转谷氨酰胺酶反应性。他们没有表现出贫血和一个腹泻。对两名患者进行了内镜检查：一名患者组织学正常，另一名患有淋巴细胞浸润和绒毛萎缩。结论：自身免疫性甲状腺疾病患者的腹腔疾病患病率为9.3％;一名患者主诉腹泻，无一例出现贫血。在高危人群中，例如自身免疫性甲状腺炎患者，不应将腹泻或贫血的存在作为指示腹腔疾病调查的标准。由于所有自身免疫性甲状腺炎的患病率很高，因此必须这样做。

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