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首页> 外文期刊>Sao Paulo Medical Journal >Interaction of lipoprotein lipase polymorphisms with body mass index and birth weight to modulate lipid profiles in children and adolescents: the CASPIAN-III Study
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Interaction of lipoprotein lipase polymorphisms with body mass index and birth weight to modulate lipid profiles in children and adolescents: the CASPIAN-III Study

机译：脂蛋白脂肪酶多态性与体重指数和出生体重的相互作用，调节儿童和青少年的脂质分布：CASPIAN-III研究

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CONTEXT AND OBJECTIVE: Interactions between body mass index (BMI), birth weight and risk parameters may contribute to diseases rather than the individual effects of each factor. However this hypothesis needs to be confirmed. This study aimed to determine to what extent variants of lipoprotein lipase (LPL) might interact with birth weight or body weight in determining the lipid profile concentrations in children and adolescents. DESIGN AND SETTING: Substudy of the third survey of a national surveillance system (CASPIAN-III Study) in Iran. METHODS: Whole blood samples (kept frozen at -70 ?°C) were randomly selected from 750 students aged 10-18 years. Real-time polymerase chain reaction (PCR) and high-resolution melt analysis were performed to assess S447X (rs328), HindIII (rs320) and D9N (rs1801177) polymorphisms. RESULTS: The AG/GG genotype in D9N polymorphism was associated with higher LDL-C (low-density lipoprotein cholesterol) and lower HDL-C (high-density lipoprotein cholesterol) concentration. Significant interactions were found for D9N polymorphism and birth weight in association with plasma HDL-C concentration, and also for D9N polymorphism and BMI in association with plasma triglyceride (TG) and HDL-C levels. HindIII polymorphism had significant association with birth weight for HDL-C concentration, and with BMI for TG and HDL-C levels. Significant interactions were found for S447X polymorphism and BMI in association with plasma TG and HDL-C concentrations. CONCLUSION: We found significant interactive effects from LPL polymorphisms and birth weight on HDL-C concentration, and also effects from LPL polymorphisms and BMI on TG and HDL-C concentrations.
机译：背景与目的：体重指数（BMI），出生体重和风险参数之间的相互作用可能导致疾病，而不是每个因素的单独影响。但是，这一假设需要得到证实。这项研究旨在确定脂蛋白脂肪酶（LPL）变异体在确定儿童和青少年脂质分布浓度时可能与出生体重或体重相互作用的程度。设计与地点：对伊朗国家监视系统的第三次调查（CASPIAN-III研究）的子研究。方法：从750名10-18岁的学生中随机抽取全血样本（保存在-70°C下冷冻）。进行实时聚合酶链反应（PCR）和高分辨率熔体分析以评估S447X（rs328），HindIII（rs320）和D9N（rs1801177）多态性。结果：D9N多态性的AG / GG基因型与较高的LDL-C（低密度脂蛋白胆固醇）和较低的HDL-C（高密度脂蛋白胆固醇）浓度有关。发现与血浆HDL-C浓度相关的D9N多态性和出生体重，以及与血浆甘油三酸酯（TG）和HDL-C水平相关的D9N多态性和BMI显着相互作用。 HindIII多态性与出生体重的HDL-C浓度显着相关，与BMI的TG和HDL-C水平显着相关。发现与血浆TG和HDL-C浓度相关的S447X多态性和BMI的显着相互作用。结论：我们发现LPL多态性和出生体重对HDL-C浓度具有显着的交互作用，LPL多态性和BMI对TG和HDL-C浓度也有显着影响。

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