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首页> 外文期刊>Science Advances >Semiconducting polymers are light nanotransducers in eyeless animals
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Semiconducting polymers are light nanotransducers in eyeless animals

机译：半导体聚合物是无眼动物中的光纳米传感器

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Current implant technology uses electrical signals at the electrode-neural interface. This rather invasive approach presents important issues in terms of performance, tolerability, and overall safety of the implants. Inducing light sensitivity in living organisms is an alternative method that provides groundbreaking opportunities in neuroscience. Optogenetics is a spectacular demonstration of this, yet is limited by the viral transfection of exogenous genetic material. We propose a nongenetic approach toward light control of biological functions in living animals. We show that nanoparticles based on poly(3-hexylthiophene) can be internalized in eyeless freshwater polyps and are fully biocompatible. Under light, the nanoparticles modify the light response of the animals, at two different levels: (i) they enhance the contraction events of the animal body, and (ii) they change the transcriptional activation of the opsin3-like gene. This suggests the establishment of a seamless and biomimetic interface between the living organism and the polymer nanoparticles that behave as light nanotransducers, coping with or amplifying the function of primitive photoreceptors.
机译：当前的植入技术使用电极-神经界面处的电信号。这种颇具侵入性的方法在性能，耐受性和植入物的整体安全性方面都提出了重要的问题。在活生物体中引起光敏感性是在神经科学领域提供开创性机会的另一种方法。光遗传学是对此的壮观展示，但受到外源遗传物质的病毒转染的限制。我们提出了一种非遗传方法来控制活体动物的生物学功能。我们表明，基于聚（3-己基噻吩）的纳米粒子可以在无眼的淡水息肉中被内化，并且具有完全的生物相容性。在光下，纳米颗粒以两种不同的水平修饰动物的光响应：（i）它们增强动物身体的收缩事件，并且（ii）它们改变视蛋白3样基因的转录激活。这表明在活生物体和充当光纳米传感器的聚合物纳米颗粒之间建立了无缝的仿生界面，以应对或增强原始感光体的功能。

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