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首页> 外文期刊>Saudi Journal of Anaesthesia >Comparison of effects of ropivacaine with and without dexmedetomidine in axillary brachial plexus block: A prospective randomized double-blinded clinical trial
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Comparison of effects of ropivacaine with and without dexmedetomidine in axillary brachial plexus block: A prospective randomized double-blinded clinical trial

机译：罗哌卡因与右美托咪定在腋下臂丛神经阻滞中的作用比较：一项前瞻性随机双盲临床试验

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Background: Addition of dexmedetomidine to ropivacaine for peripheral nerve blocks has shown to improve the efficacy of ropivacaine by prolonging the duration of analgesia. This study was undertaken to evaluate the effects of ropivacaine alone and in combination with dexmedetomidine in the axillary block. Materials and Methods: A total of 80 patients belonging to American Society of Anesthesiologists physical status I, II, and III, scheduled for elective forearm and/or hand surgeries were randomly allocated into one of the two groups to receive either 39 ml of 0.375% ropivacaine and 1 ml normal saline (Group R) or 39 ml of 0.375% ropivacaine and 1 μg/kg dexmedetomidine diluted to 1 ml with normal saline (Group RD). Results: There was a significant early the onset of sensory and the motor block in Group RD. Duration of sensory block in Group RD was 677.25 ± 99.64 min and in Group R was 494.38 ± 70.64 min and the difference was clinically significant ( P < 0.001). Duration of motor block in Group RD was 712.88 ± 89.32 min and in Group R was 526.25 ± 70.229 min and was clinically significant. Duration of analgesia in Group RD was 764.38 ± 110.275 min and that in Group R was 576.88 ± 76.306 min and was clinically significant. There was a significant alteration in hemodynamics in Group RD when compared to Group R without any side effects. Conclusion: Dexmedetomidine as an adjuvant to ropivacaine provides quicker onset of anesthesia, longer duration of analgesia. It offers convenient, simple, effective mode of anesthesia, and postoperative analgesia for forearm and/or hand surgeries.
机译：背景：罗哌卡因中添加右美托咪定可治疗周围神经阻滞，可延长止痛时间，从而提高罗哌卡因的疗效。进行这项研究以评估罗哌卡因单独使用以及与右美托咪定合用在腋窝阻滞中的作用。材料和方法：计划将80例属于美国麻醉医师协会I，II和III身体状况的患者，这些患者计划进行前臂和/或手外科手术，随机分为两组，分别接受39 ml的0.375％罗哌卡因和1 ml生理盐水（R组）或39 ml 0.375％罗哌卡因和1μg/ kg右美托咪定用生理盐水稀释至1 ml（RD组）。结果：RD组的感觉和运动阻滞发生在早期。 RD组感觉阻滞持续时间为677.25±99.64分钟，R组为494.38±70.64分钟，差异具有临床意义（P <0.001）。 RD组运动阻滞持续时间为712.88±89.32分钟，R组为526.25±70.229分钟，具有临床意义。 RD组镇痛时间为764.38±110.275分钟，R组镇痛时间为576.88±76.306分钟，具有临床意义。与R组相比，RD组的血液动力学显着改变，没有任何副作用。结论：右美托咪定可作为罗哌卡因的佐剂，麻醉起效更快，镇痛时间更长。它为前臂和/或手外科手术提供了方便，简单，有效的麻醉方式和术后镇痛方法。

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