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首页> 外文期刊>Science Journal of Chemistry >Synthesis of New Curcumin Analogues from Kulit Lawang Oils Using the Conventional Method and Microwave
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Synthesis of New Curcumin Analogues from Kulit Lawang Oils Using the Conventional Method and Microwave

机译：常规方法和微波法从古力拉扬油中合成新姜黄素类似物

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Kulit lawang oils are essential oils that are widely available in the Moluccas and oil major component contain eugenol and safrole. Safrole can be converted into value-added products that curcumin analogues. The purpose of this research is to synthesize new compounds curcumin analogues from kulit lawang oils. The steps being taken is isolation safrole, safrole isomerization and oxidation isosafrole produce piperonal. The method synthesis curcumin analogues with piperonal precursor with two methods: conventional and microwave. Results safrole isolation from skin oils mace using alkaline extraction method for 5 hours yield 19.30% were is characterized by GCMS, FTIR and 1H-NMR. Isosafrole proceeds reaction isomerization safrole without the use of solvents for 6 hours at a temperature of 120 ° C obtained yield 77.56% with two products cis-isosafrole (15.4%) and trans-isosafrole (69.34%) were characterized by GC, FTIR and 1H-NMR. Precursors piperonal which was resulting obtained from the oxidation reaction isosafrol using KMnO4 at temperature 30 °C obtained yield 65.63% were characterized by GCMS, FTIR and 1H-NMR. Results synthesis curcumin analogues (1,5-Bis-benzo [1,3] dioxol-5-yl-penta-1,4-dien-3-one) in the conventional method using 10% NaOH catalyst for 3 hours at a temperature of 25 °C be obtained yield 78.43% and synthesized using microwave at 140 watts for 2 minutes obtained yield 53.3%.
机译：Kulit lawang油是Moluccas中广泛使用的精油，并且油的主要成分包含丁香酚和黄樟脑。可以将黄樟脑转化为姜黄素类似物的增值产品。这项研究的目的是从古力拉浪油合成新的化合物姜黄素类似物。所采取的步骤是分离黄樟脑，黄樟脑异构化和氧化异黄樟脑产生胡椒醛。该方法通过两种方法与胡椒醛前体合成姜黄素类似物：常规方法和微波方法。结果采用GCMS，FTIR和1H-NMR表征，采用碱提取法从皮肤油状物中分离出黄樟脑5小时，收率19.30％。异黄酮在不使用溶剂的情况下于120°C进行6小时的反应异构化黄樟脑，得到的收率为77.56％，两种产物分别用GC，FTIR和1H表征了顺-异黄酮（15.4％）和反-异黄酮（69.34％）。 -NMR。用KMnO 4在＜30℃的温度下通过氧化反应异氟酚得到的前体胡椒醛通过GCMS，FTIR和1H-NMR表征。结果在常规方法下，在温度为10％NaOH的条件下，以常规方法合成姜黄素类似物（1,5-双-苯并[1,3]二恶唑-5-基-戊-1,4-二烯-3-酮）在25℃下，收率78.43％，用140瓦特的微波合成2分钟，收率53.3％。

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