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首页> 外文期刊>Open Pharmaceutical Sciences Journal >Optimization of Bifonazole-Loaded Nisomal Formulation Using Plackett-Burman Design and 23 Factorial Design
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Optimization of Bifonazole-Loaded Nisomal Formulation Using Plackett-Burman Design and 23 Factorial Design

机译：使用Plackett-Burman设计和23因子设计优化联苯并咪唑负载的非均质配方

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Background:Bifonazole is an imidazole antifungal drug. It is highly lipophilic drug with a very short half-life and is minimally absorbed following dermal application. Niosomes are excellent candidate as potential drug delivery system because of their improved drug solubilization, enhanced penetration power, long shelf life and ease of preparation and administration.Objective:The aim of the study was to enhance permeability of bifonazole by incorporating it into niosomes and formulating its gel formulation.Method: Niosomes were prepared by thin film hydration method. The statistical approach was used to optimize the parameters for niosome formation. The process parameters among six factors influencing in vitro diffusion study were identified using plackett burman design. The Plackett–Burnan design described in this study was applied for the identification of the significant factors and 2~(3) factorial design was used to obtain optimized batch. The prepared niosomes were evaluated for various parameters such as vesicular size, drug entrapment, surface morphology, drug release characteristics, ex vivo deposition and stability.Results:Niosomal gel showed significantly enhanced drug permeation through the skin as compared to the marketed formulation. The optimized niosomal gel formulation also showed drug release in a controlled manner. The stability study at two different temperatures (25 ± 2°C and and 5 ± 3 °C) confirmed that the optimized formulation is stable even at the end of 3 months.Conclusion:It has been concluded that niosomal gel is an efficient carrier for the delivery of bifonazole with improved permeability.
机译：背景：联苯苄唑是一种咪唑类抗真菌药。它是高度亲脂性的药物，半衰期非常短，在皮肤应用后吸收最少。脂质体具有改善的药物溶解性，增强的渗透力，较长的保质期以及易于制备和给药的特性，因此是潜在的药物传递系统的候选者。目的：本研究的目的是通过将联苯并咪唑掺入到脂质体中并提高其制剂的通透性方法：通过薄膜水化法制备脂质体。统计方法用于优化脂质体形成的参数。使用Plackett burman设计确定了影响体外扩散研究的六个因素中的工艺参数。本研究中描述的Plackett-Burnan设计用于识别重要因素，并使用2〜（3）析因设计来获得优化的批次。评价了制备的脂质体的各种参数，例如囊泡大小，药物截留，表面形态，药物释放特性，离体沉积和稳定性。结果：与市售制剂相比，Niosomal凝胶显示出显着增强的药物透过皮肤的渗透性。 。优化的基因组凝胶制剂还以受控方式显示药物释放。在两个不同温度（25±2°C和5±3°C）下的稳定性研究证实，即使在3个月的月末，优化的配方仍是稳定的。联苯并唑的渗透性得到改善。

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