• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Southern African Journal of Critical Care >An observational study on the relationship between plasma vitamin C, blood glucose, oxidative stress, endothelial dysfunction and outcome in patients with septic shock
【24h】

An observational study on the relationship between plasma vitamin C, blood glucose, oxidative stress, endothelial dysfunction and outcome in patients with septic shock

机译：败血性休克患者血浆维生素C，血糖，氧化应激，内皮功能障碍与预后的关系的观察性研究

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

BACKGROUND. Septic shock is associated with endothelial dysfunction and oxidative stress, against which vitamin C plays a protective role, possibly influencing clinical outcome. Hyperglycaemia may lower vitamin C. OBJECTIVE. To study plasma vitamin C, oxidative stress, hyperglycaemia, endothelial dysfunction and outcome in septic shock. METHODS. In a prospective, observational study of 25 adult septic shock patients, serial blood samples were analysed for vitamin C, thiobarbituric acid-reactive substances (TBARS) (a biomarker of oxidative stress), and soluble vascular cell adhesion molecule-1 (sVCAM-1) and E-selectin (markers of endothelial dysfunction). Blood glucose, Sequential Organ Failure Assessment (SOFA) scores and fluid requirements were monitored. RESULTS. Plasma vitamin C was low, while plasma TBARS were high throughout the 7-day study period. Endothelial dysfunction markers (sVCAM-1 and E-selectin) were high at the baseline. VCAM-1 decreased significantly on day 1 and normalised on day 7. E-selectin was unchanged on day 1 compared with baseline, but increased significantly on day 7. Oxidative stress and endothelial dysfunction were associated with increased SOFA score. Increased oxidative stress was associated with increased requirements for intravenous fluids and prolonged duration of vasoconstrictor support. Nine patients died in hospital. At baseline, levels of TBARS were significantly higher in non-survivors than in the survivors of septic shock. CONCLUSION. In septic shock, clinically relevant oxidative stress was associated with endothelial dysfunction, low vitamin C and high glucose-to-vitamin-C ratios. Markers of oxidative stress and endothelial damage were increased and correlated with resuscitation fluid requirements, vasoconstrictor use, organ failure and mortality.
机译：背景。败血性休克与内皮功能障碍和氧化应激有关，维生素C对此起保护作用，可能影响临床结果。高血糖症可能会降低维生素C。目标。研究血浆维生素C，氧化应激，高血糖，内皮功能障碍和败血性休克的结局。方法。在一项针对25名成人败血性休克患者的前瞻性观察研究中，分析了连续血样中的维生素C，硫代巴比妥酸反应性物质（TBARS）（氧化应激的生物标志物）和可溶性血管细胞粘附分子1（sVCAM-1） ）和E-选择素（内皮功能障碍的标志物）。监测血糖，序贯器官衰竭评估（SOFA）分数和体液需求。结果。在整个7天的研究期内，血浆维生素C较低，而血浆TBARS较高。基线时内皮功能障碍标志物（sVCAM-1和E-选择素）较高。 VCAM-1在第1天显着下降，并在第7天恢复正常。与基线相比，第1天E-选择素没有变化，但在第7天显着增加。氧化应激和内皮功能障碍与SOFA评分升高有关。氧化应激增加与静脉输液的需求增加以及血管收缩支持的持续时间延长有关。九名患者在医院死亡。在基线时，非幸存者的TBARS水平显着高于败血性休克幸存者的TBARS水平。结论。在败血性休克中，临床上相关的氧化应激与内皮功能障碍，低维生素C和高葡萄糖/维生素C比有关。氧化应激和内皮损伤的标志物增加，并与复苏液需求，血管收缩剂的使用，器官衰竭和死亡率相关。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号