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首页> 外文期刊>Revista chilena de pediatría >Uso Racional de Corticoides en el Paciente con Shock Séptico
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Uso Racional de Corticoides en el Paciente con Shock Séptico

机译:感染性休克患者中合理使用皮质类固醇激素

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Introduction: Septic shock (SS) is a significant cause of mortality in NICUs. Objective: Review current knowledge on Hypothalamic-Pituitary-Adrenal Axis (HPA) and the scientific support for the use of gluco-corticoids in the use of this clinical picture. We know that the patient's ability to evolve into improvement or worsening depends upon the ability of the HPA axis to develop and sustain an adequate response to the stress provoked by SS. In some patients, due to many reasons, the prolongation of SS leads to a deficit of cortisol those results in functional acute adrenal insufficiency. Cortisol levels do not respond to ACTH stimulation test. There is no consensus among authors as to what is a normal concentration of cortisol during stress, or even if it is correlated with death among children with SS. The American College of Critical Care Medicine guidelines for SS in Pediatrics and Neonatology have made some recommendations for use of hydrocortisone.
机译:简介:败血性休克(SS)是重症监护病房(NCCU)死亡的重要原因。目的:回顾当前关于下丘脑-垂体-肾上腺轴(HPA)的知识以及在此临床图片中使用糖皮质激素的科学支持。我们知道,患者发展为改善或恶化的能力取决于HPA轴对SS引起的压力发展并维持适当反应的能力。在某些患者中,由于多种原因,SS的延长导致皮质醇不足,导致功能性急性肾上腺功能不全。皮质醇水平对ACTH刺激试验无反应。关于压力期间皮质醇的正常浓度,甚至与SS儿童的死亡相关,作者之间尚无共识。美国重症医学专科学院儿科和新生儿科SS指南已提出了使用氢化可的松的一些建议。

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