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The genome anatomy of Corynebacterium pseudotuberculosis VD57 a highly virulent strain causing Caseous lymphadenitis

机译:假性棒状杆菌VD57(一种引起干酪性淋巴结炎的高毒力菌株)的基因组解剖

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Corynebacterium pseudotuberculosis strain VD57 (Cp_VD57), a highly virulent, nonmotile, non-sporulating, and a mesophilic bacterium, was isolated from a goat’s granulomatous lesion in the municipality of Juazeiro, Bahia State, Brazil. Here, we describe a set of features of the strain, together with the details of its complete genome sequence and annotation. The genome comprises of a 2.5 Mbp long, single circular genome with 2,101 protein-coding genes, 12 rRNA, 49 tRNA and 47 pseudogenes and a G?+?C content of 52.85?%. Genetic variation was detected in Cp_VD57 using C. pseudotuberculosis strain 1002 as reference, wherein small genomic insertions and deletions were identified. The comparative analysis of the genome sequence provides means to better understand the host pathogen interactions of this strain and can also help us to understand the molecular and genetic basis of virulence of this bacterium.
机译:从巴西巴伊亚州Juazeiro市的山羊肉芽肿病灶中分离出一种高毒力,不运动,不产芽孢和嗜温细菌的假结核棒状杆菌菌株VD57(Cp_VD57)。在这里,我们描述了该菌株的一组特征,以及其完整基因组序列和注释的详细信息。该基因组由一个2.5 Mbp长的单环状基因组组成,具有2,101个蛋白质编码基因,12个rRNA,49个tRNA和47个假基因,Gδ+δC含量为52.85%。使用假结核梭菌菌株1002作为参考,在Cp_VD57中检测到遗传变异,其中鉴定出小的基因组插入和缺失。基因组序列的比较分析为更好地了解该菌株的宿主病原体之间的相互作用提供了手段,也可以帮助我们了解这种细菌毒力的分子和遗传基础。

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