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首页> 外文期刊>Revista Chilena de Neuropsiquiatria >Rash y anemia aplásica inducidos por fenitoína: caso clínico
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Rash y anemia aplásica inducidos por fenitoína: caso clínico

机译:苯妥英钠引起的皮疹和再生障碍性贫血:临床病例

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Rash is a common side effect associated with antiepileptic drugs. The rate of a phenytoin rash is 5.9% and increases to 25% in those with another antiepileptic drug rash. Aplastic anemia is an adquired hematopoietic stem-cell disorder characterized by pancytopenia of the peripheral blood and hypocellular bone marrow. The use of phenytoin is associated with a 3.5 fold increased risk of aplastic anemia. We report a case of a 70-year-old woman who developed two severe adverse reactions simultaneously with phenytoin: a maculopapular pruritic rash with involvement of mucous and an aplastic anemia. Both conditions normalized after phenytoin withdrawal.
机译:皮疹是与抗癫痫药相关的常见副作用。苯妥英类皮疹的发生率为5.9%,在发生另一种抗癫痫药皮疹的患者中,这一比率上升至25%。再生障碍性贫血是一种必需的造血干细胞疾病,其特征是外周血和细胞低层骨髓的全血细胞减少。苯妥英钠的使用与再生障碍性贫血的风险增加了3.5倍有关。我们报道了一例70岁的女性,该女性同时与苯妥英钠同时发生了两种严重的不良反应:斑斑性丘疹性皮疹伴粘液和再生障碍性贫血。苯妥英钠停用后,两种情况均恢复正常。

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