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首页> 外文期刊>Pakistan journal of medical sciences. >Seroprevalence of Cytomegalovirus infection and estimate of congenital Cytomegalovirus infection in Isfahan state, Iran: A population based study
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Seroprevalence of Cytomegalovirus infection and estimate of congenital Cytomegalovirus infection in Isfahan state, Iran: A population based study

机译：伊朗伊斯法罕州巨细胞病毒感染的血清流行率和先天性巨细胞病毒感染的估计：一项基于人群的研究

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Objective: Cytomegalovirus (CMV) is a well-known virus with major consequences in growing fetus, premature infants, and immune deficient individuals. There are few reports in prevalence of CMV infection in Iran, mainly in pregnant women. We conducted an epidemiological study to investigate the age-stratified seroprevalence and epidemiological characteristics of CMV infection in total inhabitants of Isfahan state, central Iran. Methodology: In a cross sectional study 595 serum samples which were collected randomly from total population of Isfahan state, Iran were used for IgG anti-CMV antibody titration by a commercial enzyme-linked immunosorbent assay (ELISA) kit. Data were analyzed by Statistical Package for Social Sciences for Windows version 15(SPSS). Chi-squar and Fisher exact tests were applied to determine antibody status in different age, gender, education, family member, and residency groups. Results: The overall prevalence was 98.2 %( 586/595). The prevalence in age groups of 6-9, 10-19, 20-29, 30-39, 40-49 and above 49 years were 95.7, 98.6, 97.8, 100, 96.6, and 100 percent respectively. There was no statistical significant association between CMV seroprevalence with age, gender, education, family member, and residency groups (P < 0.05). Conclusions: This study elucidates a very high prevalence of CMV infection in population which acquired it from early childhood. So it is necessary to initiate measures to reduce the burden of CMV disease in fetuses, premature infants, and immune deficient individuals. To treat hearing loss in inapparent congenitally infected infants, repeated auditory exams up to 5 years old has paramount importance.
机译：目的：巨细胞病毒（CMV）是一种众所周知的病毒，会对胎儿，早产儿和免疫缺陷个体的成长产生重大影响。在伊朗，主要在孕妇中，很少有关于CMV感染的报道。我们进行了一项流行病学研究，以调查伊朗中部伊斯法罕州全部居民中CMV感染的年龄分层血清流行率和流行病学特征。方法：在一项横断面研究中，从伊朗伊斯法罕州总人口中随机收集的595个血清样品通过商业酶联免疫吸附测定（ELISA）试剂盒用于IgG抗CMV抗体滴定。通过Windows 15版（SPSS）的社会科学统计软件包对数据进行了分析。应用Chi-squar和Fisher精确测试来确定不同年龄，性别，受教育程度，家庭成员和居住群体中抗体的状态。结果：总体患病率为98.2％（586/595）。 6-9岁，10-19岁，20-29岁，30-39岁，40-49岁和49岁以上年龄段的患病率分别为95.7％，98.6％，97.8％，100％，96.6％和100％。 CMV血清阳性率与年龄，性别，受教育程度，家庭成员和居住群体之间无统计学意义的相关性（P <0.05）。结论：这项研究阐明了从儿童早期就感染CMV的人群的患病率很高。因此，有必要采取措施减轻胎儿，早产儿和免疫缺陷个体的CMV疾病负担。为了治疗不明显的先天性感染婴儿的听力丧失，至多5岁的反复听觉检查至关重要。

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