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首页> 外文期刊>Pakistan journal of medical sciences. >Identification and antibiotic susceptibility pattern of coagulase-negative staphylococci in various clinical specimens
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Identification and antibiotic susceptibility pattern of coagulase-negative staphylococci in various clinical specimens

机译：各种临床标本中凝固酶阴性葡萄球菌的鉴定和抗生素敏感性模式

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Objective: Antibiotic resistance is a global problem and is more prevalent in developing countries. Coagulase-negative staphylococci (CoNS) are recognized as important pathogen for nosocomial infections. This study was carried out to identify CoNS in various clinical specimens and to determine its antimicrobial susceptibility pattern.Methods: A total of 2989 specimens of blood, pus and wound swab were collected from wards, casualty, ICU and OPD, out of these, staphylococci were isolated in 1000 specimens, of which 381 were identified as CoNS. Culture, gram stain, catalase, coagulase test and antimicrobial susceptibility pattern were done according to clinical manual of microbiology. A total of fourteen antibiotics were used in this study. Susceptibility testing was done by Kirby Bauer disc diffusion technique.Results: Antimicrobial resistance of CoNS were Oxacillin (70.3%), Amoxicillin (74.8%), Amoxicillin+clavulanate (32.8%), Ciprofloxacin (35.2%), Ofloxacin (33.6%), Ceftriaxone (30.4%), Erythromycin (58.3%), Clindamycin (16.3%), Daptomycin (42.5%), Kanamycin (52.2%), Fusidic acid (41.7%), Doxycycline (24.7%), Vancomycin (2.6%) and Linezolid (0.8%). Maximum Oxacillin resistance was between 80 to 90 percent in a group of patients having age of 45 to 65 years and those suffering from cancer or admitted in ICU.Conclusion: The study concluded that CoNS showed significant level of resistance against most of the widely used therapeutic agents.?doi: http://dx.doi.org/10.12669/pjms.296.4064 How to cite this:Ehsan MM, Memon Z, Ismail MO, Fatima G. Identification and antibiotic susceptibility pattern of coagulase-negative staphylococci in various clinical specimens. Pak J Med Sci 2013;29(6):1420-1424. doi: http://dx.doi.org/10.12669/pjms.296.4064This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
机译：目的：抗生素耐药性是一个全球性问题，在发展中国家更为普遍。凝固酶阴性葡萄球菌（CoNS）被认为是医院感染的重要病原体。这项研究旨在鉴定各种临床标本中的CoNS并确定其抗菌药敏性方法。方法：从病房，伤员，ICU和OPD中共采集2989个血液，脓液和伤口拭子标本，其中包括葡萄球菌分离出1000个标本，其中381个被鉴定为CoNS。根据微生物学的临床手册进行培养，革兰氏染色，过氧化氢酶，凝固酶测试和抗菌药敏试验。这项研究总共使用了十四种抗生素。结果：CoNS的耐药性为：奥沙西林（70.3％），阿莫西林（74.8％），阿莫西林+克拉​​维酸盐（32.8％），环丙沙星（35.2％），氧氟沙星（33.6％），头孢曲松钠（30.4％），红霉素（58.3％），克林霉素（16.3％），达托霉素（42.5％），卡那霉素（52.2％），夫西地酸（41.7％），强力霉素（24.7％），万古霉素（2.6％）和利奈唑胺（0.8％）。年龄在45至65岁之间，患有癌症或入住ICU的一组患者中最大的奥沙西林耐药率在80％至90％之间。结论：该研究得出结论，CoNS对大多数广泛使用的治疗药物显示出显着的耐药水平doi：http：//dx.doi.org/10.12669/pjms.296.4064如何引用：Ehsan MM，Memon Z，Ismail MO，FatimaG。各种临床上凝固酶阴性葡萄球菌的鉴定和抗生素敏感性模式标本。 Pak J Med Sci 2013; 29（6）：1420-1424。 doi：http://dx.doi.org/10.12669/pjms.296.4064这是根据知识共享署名许可（http://creativecommons.org/licenses/by/3.0）的条款分发的开放访问文章，只要适当引用了原始作品，便可以在任何介质中不受限制地使用，分发和复制。

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