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首页> 外文期刊>Pakistan journal of medical sciences. >Ear infections in Karachi: The frequency and antibiotic resistance of bacterial isolates
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Ear infections in Karachi: The frequency and antibiotic resistance of bacterial isolates

机译：卡拉奇的耳朵感染：细菌分离株的发生频率和耐药性

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Objective: This 12-month retrospective study was undertaken to determine the frequency of ear infections in children and adults, and the sensitivity of bacterial isolates to antibiotics available for their treatment Methodology: Ear swabs of 197 subjects with ear infections were processed in a local lab with branches in key areas of Karachi City from January 2009 to December 2009. The isolates from ear discharge were identified on conventional basis and their sensitivity to 24 antibiotics was determined by the Kirby-Bauer Agar Disc Diffusion Method. Results: Among the patients, 100 were females and 97 males; infections were more common in children between 1 to 10 years. Staphylococcus aureus and Pseudomonas aeruginosa were mostly isolated among 10 bacterial species; Klebsiella pneumoniae was more often grown from female infected ears. The most effective antibiotics determined for possible empirical prescription included Pipericillin+Tazobactam, Cefoperazone+Sulbactam, Imipenam, and Fosfomycin. While Ciprofloxacin (57.7%) and Amoxyclav (36.2%) exerted transitional activity, a majority of the isolates were indifferent to Cotrimoxazole, Cefixime, Lincomycin, Doxycycline and Polymyxin B. Conclusion: The increasing resistance of causative organisms in our environment to multiple antibiotics encourages the C/S of specimens prior to drug prescription in order to reduce the chances of treatment failure and amplified antibiotic resistance. When unavoidable, however, a selection of drugs is offered for empirical preference.
机译：目的：这项为期12个月的回顾性研究旨在确定儿童和成人耳部感染的频率，以及细菌分离株对可用于治疗的抗生素的敏感性方法：在当地实验室对197名耳部感染受试者的耳拭子进行了处理于2009年1月至2009年12月在卡拉奇市的主要地区设有分支机构。按常规鉴定了耳分泌物的分离株，并通过Kirby-Bauer琼脂圆盘扩散法确定了它们对24种抗生素的敏感性。结果：患者中女性100例，男性97例。感染在1至10岁的儿童中更为常见。金黄色葡萄球菌和铜绿假单胞菌主要分离于10种细菌中。肺炎克雷伯菌通常来自女性感染的耳朵。在可能的经验处方中确定的最有效的抗生素包括哌青霉素+他唑巴坦，头孢哌酮+舒巴坦，依匹南和磷霉素。环丙沙星（57.7％）和阿莫克拉韦（36.2％）发挥过渡活性，但大多数分离株对复方新诺明，头孢克肟，林可霉素，强力霉素和多粘菌素B漠不关心。在开药之前标本的C / S，以减少治疗失败的机会和增强的抗生素耐药性。但是，在不可避免的情况下，会根据经验选择药物。

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