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Poor medication adherence in type 2 diabetes: recognizing the scope of the problem and its key contributors

机译:2型糖尿病药物依从性差:认识到问题的范围及其主要贡献者

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At least 45% of patients with type 2 diabetes (T2D) fail to achieve adequate glycemic control (HbA1c <7%). One of the major contributing factors is poor medication adherence. Poor medication adherence in T2D is well documented to be very common and is associated with inadequate glycemic control; increased morbidity and mortality; and increased costs of outpatient care, emergency room visits, hospitalization, and managing complications of diabetes. Poor medication adherence is linked to key nonpatient factors (eg, lack of integrated care in many health care systems and clinical inertia among health care professionals), patient demographic factors (eg, young age, low education level, and low income level), critical patient beliefs about their medications (eg, perceived treatment inefficacy), and perceived patient burden regarding obtaining and taking their medications (eg, treatment complexity, out-of-pocket costs, and hypoglycemia). Specific barriers to medication adherence in T2D, especially those that are potentially modifiable, need to be more clearly identified; strategies that target poor adherence should focus on reducing medication burden and addressing negative medication beliefs of patients. Solutions to these problems would require behavioral innovations as well as new methods and modes of drug delivery.
机译:至少45%的2型糖尿病(T2D)患者未能实现足够的血糖控制(HbA1c <7%)。主要的影响因素之一是药物依从性差。在T2D中药物依从性差是非常普遍的现象,并与血糖控制不足有关。发病率和死亡率增加;以及增加门诊护理,急诊室就诊,住院和管理糖尿病并发症的成本。药物依从性差与关键的非患者因素(例如,许多医疗体系中缺乏综合护理以及医护人员的临床惯性),患者人口统计学因素(例如,年轻人,低学历和低收入水平),严重性有关。患者对他们的药物的信念(例如,感知的治疗无效),以及患者对于获得和服用药物的负担(例如,治疗复杂性,自付费用和低血糖症)。需要更明确地确定在T2D中依从性的具体障碍,尤其是那些可能被修改的障碍;针对依从性差的策略应侧重于减轻药物负担并解决患者对药物的消极信念。解决这些问题将需要行为创新以及新的药物输送方法和方式。

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