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首页> 外文期刊>Patient Preference and Adherence >Persistence and adherence in multiple sclerosis patients starting glatiramer acetate treatment: assessment of relationship with care received from multiple disciplines
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Persistence and adherence in multiple sclerosis patients starting glatiramer acetate treatment: assessment of relationship with care received from multiple disciplines

机译：开始使用醋酸格拉替雷治疗的多发性硬化症患者的持续性和依从性：评估与多学科治疗的关系

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Background: In multiple sclerosis patients, the persistence of, and adherence to, disease-modifying treatment are often insufficient. The degree of persistence and adherence may relate to the care received from various disciplines. Methods: In an observational study of 203 patients treated with glatiramer acetate 20 mg subcutaneous daily, we assess the persistence and adherence in relation to the amount of care received in various disciplines. The frequencies and durations of care per discipline were reported by patients online, as were missed doses and eventual treatment discontinuation. The associations between the care provided by neurologists, nurses, psychologists, pharmacists, and rehabilitative doctors and persistence and adherence were the primary outcomes; the associations between care received from general practitioners, occupational therapists, physiotherapists, social workers, dieticians, home caregivers, informal caregivers, other medical specialists, and other caregivers and persistence and adherence were secondary outcomes. Results: It was found that the 12-month persistence rate was 62% and that 85% of the persistent patients were 95% adherent (missed <5% of doses). Patients who discontinued treatment in the fourth quarter (Q) had received less-frequent and shorter psychological care in Q3 than persistent patients ( P =0.0018 and P =0.0022). Adherent patients had received more frequent home care and informal care than nonadherent patients ( P =0.0074 and P =0.0198), as well as longer home care and informal care ( P =0.0074 and P =0.0318). Associations between care in other disciplines and persistence or adherence were not observed. As to the relationship between adherence and persistence, nonadherence in Q2 was related to discontinuation after Q2 ( P =0.0001). Conclusion: We obtained no evidence that, in multiple sclerosis patients, persistence of and adherence to disease-modifying treatment are associated with the amount of neurological, nursing, pharmaceutical, or rehabilitative care. However, findings suggest that the treatment of psychological problems in Q3 may relate to persistence and that home care and informal care may relate to adherence.
机译：背景：在多发性硬化症患者中，疾病缓解疗法的坚持性和坚持性常常不足。坚持和遵守的程度可能与从各个学科获得的照顾有关。方法：在一项观察性研究中，每天皮下注射20毫克醋酸格拉替雷20例，我们评估了各个学科所接受的护理的持久性和依从性。患者在线报告了每门学科的护理频率和持续时间，以及错过的剂量和最终的治疗终止。主要的结果是神经科医生，护士，心理学家，药剂师和康复医生所提供的护理与坚持与坚持的联系。从全科医生，职业治疗师，物理治疗师，社会工作者，营养师，家庭护理人员，非正式护理人员，其他医学专家和其他护理人员获得的护理与持久性和依从性之间的关联是次要结果。结果：发现12个月的持久性率为62％，而85％的持久性患者为95％依从性（漏服剂量小于5％）。与持续性患者相比，在第四季度（Q）中止治疗的患者在第三季度接受较少的频率和较短的心理护理（P = 0.0018和P = 0.0022）。坚持治疗的患者比非坚持治疗的患者接受更频繁的家庭护理和非正式护理（P = 0.0074和P = 0.0198），以及更长的家庭护理和非正式护理（P = 0.0074和P = 0.0318）。没有观察到其他学科的护理与坚持或坚持之间的关联。关于坚持与坚持之间的关系，第二季度的不坚持与第二季度后的停药有关（P = 0.0001）。结论：我们没有证据表明，在多发性硬化症患者中，坚持和坚持改变疾病的治疗方法与神经，护理，药物或康复治疗的数量有关。但是，研究结果表明，第三季度对心理问题的治疗可能与持久性有关，而家庭护理和非正式护理可能与依从性有关。

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