...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Pediatric Investigation >Serotypes of human enteroviruses causing pediatric viral encephalitis and meningitis in Hebei province, China, from 2013 to 2015
【24h】

Serotypes of human enteroviruses causing pediatric viral encephalitis and meningitis in Hebei province, China, from 2013 to 2015

机译：2013年至2015年中国河北省引起小儿病毒性脑炎和脑膜炎的人类肠道病毒血清型

获取原文
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Importance Viral encephalitis and meningitis are severe infectious diseases responsible for substantial morbidity and mortality in children. Enteroviruses are typically the most common causative agents of viral encephalitis and meningitis. Objective This study aimed to investigate the etiology of viral encephalitis and meningitis among children in Hebei province, China. Methods Cerebrospinal fluid samples from children with viral encephalitis (n=309) and meningitis (n=133) were collected between Nov 2013 and Dec 2015 and viral pathogens were identified by real‐time and multiplex PCR. Amplification and sequencing of partial VP1 genes was used to type enteroviruses. Results The causative pathogen was successfully detected in 176 (57%) patients with viral encephalitis and 82 (61.7%) patients with viral meningitis. The most common causative agents of both viral encephalitis and meningitis were enteroviruses (55.7% and 64.6% of cases, respectively). The most common enterovirus serotypes identified were echovirus 18, echovirus 6 and echovirus 30. Echovirus 18 accounted for 74.4% of all typed enteroviruses and caused a viral encephalitis and meningitis outbreak in Hebei province in 2015. By contrast, the major enterovirus serotypes circulating in 2014 were echovirus 6 and echovirus 30. Interpretation Enteroviruses were the main causative agents of viral encephalitis and meningitis in children in Hebei province from Nov 2013 to Dec 2015. Echovirus 18 became the leading cause of viral encephalitis and meningitis for the first time in Hebei province in 2015.
机译：重要性病毒性脑炎和脑膜炎是导致儿童大量发病和死亡的严重传染病。肠病毒通常是病毒性脑炎和脑膜炎的最常见病原体。目的探讨河北省儿童病毒性脑炎和脑膜炎的病因。方法在2013年11月至2015年12月期间，从病毒性脑炎（n = 309）和脑膜炎（n = 133）患儿收集脑脊液样本，并通过实时和多重PCR鉴定病毒病原体。使用部分VP1基因的扩增和测序来鉴定肠病毒。结果在176例（57％）病毒性脑炎患者和82例（61.7％）病毒性脑膜炎患者中成功检出了病原体。病毒性脑炎和脑膜炎最常见的病因是肠病毒（分别占55.7％和64.6％）。鉴定出的最常见的肠病毒血清型是echovirus 18，echovirus 6和echovirus30。Echovirus18占2015年河北省所有类型肠病毒的74.4％，并引起了病毒性脑炎和脑膜炎的爆发。相比之下，2014年流行的主要肠病毒血清型2013年11月至2015年12月，肠病毒是河北省儿童病毒性脑炎和脑膜炎的主要病原体。肠病毒是18岁以来首次成为病毒性脑炎和脑膜炎的主要原因。 2015年。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号