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In Vivo Study for Anti-inflammatory Activity of Bauhinia variegata L.Leaves

机译：紫荆花叶的抗炎活性的体内研究

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Bauhinia variegata L. (Rakta kanchan) has been traditionally used in India for treatment of a variety of inflammatoryconditions, skin diseases, stomatitis, leprosy and for wound healing. Using mostly in vitro models, a numberof published reports confirmed the anti-inflammatory potential of the leaves, bark and roots of this tree. The isolation of abioactive triterpene saponin from the leaves and a flavonol glycoside from the roots has also been reported. In the presentstudy, we have evaluated the anti-inflammatory activity of the leaf extract of B. variegata, using three in vivo animalmodels: the carrageenan induced rat paw edema, cotton pellets induced granuloma formation, and adjuvant induced arthritisin rat. Both the ethanol extract and the petroleum ether fraction obtained from this extract demonstrated activity in allthe three bioassays. The activity was found to be more pronounced in the petroleum ether fraction. These bioactivitiescompared favorably with diclofenac sodium, which was used as positive control, and confirms the traditional usefulnessof this plant for the treatment of both acute and chronic inflammatory conditions.
机译：紫荆花（Rakta kanchan）在印度传统上用于治疗各种炎症，皮肤病，口腔炎，麻风病和伤口愈合。使用大多数体外模型，许多已发表的报告证实了该树的叶子，树皮和根的抗炎潜力。也已经报道了从叶中分离出具有生物活性的三萜皂苷和从根中分离出黄酮醇苷。在本研究中，我们使用三种体内动物模型评估了百日草叶片提取物的抗炎活性：角叉菜胶诱导的大鼠爪水肿，棉丸诱导的肉芽肿形成和佐剂诱导的关节炎。乙醇提取物和从该提取物中获得的石油醚馏分在所有三种生物测定中均显示出活性。发现该活性在石油醚馏分中更明显。这些生物活性与用作阳性对照的双氯芬酸钠相比具有优势，证实了该植物在治疗急性和慢性炎症方面的传统用途。

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