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首页> 外文期刊>Pharmacognosy Research >Vitex negundo inhibits cyclooxygenase-2 inflammatory cytokine-mediated inflammation on carrageenan-induced rat hind paw edema
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Vitex negundo inhibits cyclooxygenase-2 inflammatory cytokine-mediated inflammation on carrageenan-induced rat hind paw edema

机译：荆条抑制角叉菜胶诱导的大鼠后爪水肿的环氧合酶2炎症性细胞因子介导的炎症

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Background:Vitex negundo L. (Verbenaceae) is a hardy plant widely distributed in the Indian subcontinent and used for treatment of a wide spectrum of health disorders in traditional and folk medicine, some of which have been experimentally validated. In present study, we aimed to investigate the anti-inflammatory effects of V. negundo in carrageenan-induced paw edema in rats, and to investigate the probable mechanism of anti-inflammatory action.Materials and Methods:Paw edema was produced by injecting 1% solution of carrageenan, and the paw volume was measured before and after carrageenan injection up to 5 h. V. negundo leaf oil was extracted using a Clevenger apparatus and administered by a trans-dermal route to Wistar rats and the percentage of inhibition of inflammation was observed using a Plethysmometer by comparing a compound aerosol-based formulation with 1 mg diclofinac diethylamine BP and 7 mg methyl salicylate IP/kg body weight served as a standard drug whereas paraffin oil served as the placebo group. After withdrawing of blood, serum was separated and cyclooxygenase (COX)-1 and COX-2 inhibitory activities were measured by the enzyme immuno assay (EIA) method by using a COX inhibitor screening assay kit.Results and Discussion:V. negundo leaf oil significantly (P < 0.05) reduced the carrageenan-induced paw edema as compared to the placebo group (paraffin oil) and 1 mg diclofinac diethylamine BP and 7 mg methyl salicylate IP showed the maximum inhibition of paw edema as compared to the V. negundo leaf oil treated group and the control group. Also in the present study V. negundo leaf oil showed significantly (P < 0.05) inhibits COX-1 pathways rather than COX-2 pathways as compared to the V. negundo leaf oil treated group.Conclusion:It is suggested that the V. negundo leaf oil is a potent anti-inflammatory agent and acts via inhibition of COX-2 without much interfering COX-1 pathways.
机译：背景：黄荆（Vitex negundo L。）（马鞭草科）是一种强壮的植物，广泛分布于印度次大陆，用于治疗传统和民间医学中的多种健康疾病，其中一些已通过实验验证。在本研究中，我们的目的是研究V. negundo对角叉菜胶诱发的大鼠足水肿的抗炎作用，并探讨其抗炎作用的可能机制。材料与方法：注射1％的水产生足水肿。角叉菜胶的溶液，并在注射角叉菜胶之前和之后直至5小时测量爪子体积。使用Clevenger仪器提取白蜡树叶油，并通过经皮途径对Wistar大鼠给药，并通过容积描记器将复合气雾剂与1 mg双氯芬酸二乙胺BP和7进行比较，观察到炎症抑制的百分比。毫克水杨酸甲酯IP /千克体重为标准药物，石蜡油为安慰剂组。抽血后，分离血清，并使用酶联免疫吸附抑制剂筛选测定试剂盒，通过酶联免疫法（EIA）测定环氧合酶（COX）-1和COX-2的抑制活性。与安慰剂组（石蜡油）相比，白鹭叶油显着（P <0.05）减轻了角叉菜胶诱发的爪水肿，与V相比，1 mg双氯芬酸二乙胺BP和7 mg水杨酸IP显示最大的爪水肿抑制negundo叶油治疗组和对照组。同样在本研究中，与紫茎泽兰叶油治疗组相比，紫茎泽兰叶油显示出显着（P <0.05）抑制COX-1途径而不是COX-2途径的结论。叶油是一种有效的抗炎药，可通过抑制COX-2发挥作用，而不会过多干扰COX-1途径。

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