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首页> 外文期刊>Physiological Reports >Female rats are more susceptible to central nervous system oxygen toxicity than male rats
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Female rats are more susceptible to central nervous system oxygen toxicity than male rats

机译：雌性大鼠比雄性大鼠更容易受到中枢神经系统的氧气中毒

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AbstractTonic–clonic seizures typify central nervous system oxygen toxicity (CNS-OT) in humans and animals exposed to high levels of oxygen, as are encountered during scuba diving. We previously demonstrated that high doses of pseudoephedrine (PSE) decrease the latency to seizure (LS) for CNS-OT in young male rats. This study investigated whether female rats respond similarly to PSE and hyperbaric oxygen (HBO). We implanted 60 virgin stock (VS) and 54 former breeder (FB) female rats with radio-telemetry devices that measured brain electrical activity. One week later, rats were gavaged with saline or PSE in saline (40, 80, 120, 160, or 320 mg/kg) before diving to five atmospheres absolute in 100% oxygen. The time between reaching maximum pressure and exhibiting seizure was LS. Vaginal smears identified estrus cycle phase. PSE did not decrease LS for VS or FB, primarily because they exhibited low LS for all conditions tested. VS had shorter LS than males at 0, 40, and 80 mg/kg (−42, −49, and −57%, respectively). FB also had shorter LS than males at 0, 40, and 80 mg/kg (−60, −86, and −73%, respectively). FB were older than VS (286 ± 10 days vs. 128 ± 5 days) and weighed more than VS (299 ± 2.7 g vs. 272 ± 2.1 g). Males tested were younger (88 ± 2 days), heavier (340 ± 4.5 g), and gained more weight postoperatively (7.2 ± 1.6 g) than either VS (−0.4 ± 1.5 g) or FB (−1.6 ± 1.5 g); however, LS correlated poorly with age, body mass, change in body mass, and estrus cycle phase. We hypothesize that differences in sex hormones underlie females' higher susceptibility to CNS-OT than males.
机译：摘要强直性阵挛性癫痫发作是水肺潜水过程中暴露于高水平氧气的人和动物的中枢神经系统氧气中毒（CNS-OT）的典型代表。我们以前证明，高剂量的伪麻黄碱（PSE）可以减少年轻雄性大鼠中枢神经系统兴奋剂（OTS）发作的潜伏期（LS）。这项研究调查了雌性大鼠对PSE和高压氧（HBO）的反应是否相似。我们给60只处女（VS）和54只前种犬（FB）雌性大鼠植入了可测量大脑电活动的无线电遥测设备。一周后，在100％氧气中潜水至5个绝对大气压之前，将大鼠或生理盐水（40、80、120、160或320 mg / kg）中的PSE灌胃。从达到最大压力到出现癫痫发作的时间为LS。阴道涂片确定发情周期的阶段。 PSE不会降低VS或FB的LS，主要是因为它们在所有测试条件下均显示出低LS。在0、40和80 mg / kg时，VS的LS短于雄性（分别为-42，-49和-57％）。 FB在0、40和80 mg / kg时的LS也比男性短（分别为-60％，-86％和-73％）。 FB比VS大（286±10天vs.128±5天），重于VS（299±2.7 g对272±2.1 g）。测试的男性比VS（-0.4±1.5 g）或FB（-1.6±1.5 g）年轻（88±2天），重（340±4.5 g），术后体重增加（7.2±1.6 g）;然而，LS与年龄，体重，体重变化和发情周期阶段之间的相关性很差。我们假设性激素的差异是女性对中枢神经系统OT的敏感性高于男性的基础。

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