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首页> 外文期刊>Physiological Reports >Vascular smooth muscle cell contraction and relaxation in the isolated aorta: a critical regulator of large artery compliance
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Vascular smooth muscle cell contraction and relaxation in the isolated aorta: a critical regulator of large artery compliance

机译：离体主动脉中的血管平滑肌细胞收缩和松弛：大动脉顺应性的关键调节剂

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Over the past few decades, isometric contraction studies of isolated thoracic aorta segments have significantly contributed to our overall understanding of the active, contractile properties of aortic vascular smooth muscle cells (VSMCs) and their cross‐talk with endothelial cells. However, the physiological role of VSMC contraction or relaxation in the healthy aorta and its contribution to the pulse‐smoothening capacity of the aorta is currently unclear. Therefore, we investigated the acute effects of VSMC contraction and relaxation on the isobaric biomechanical properties of healthy mouse aorta. An in‐house developed set‐up was used to measure isobaric stiffness parameters of periodically stretched (10?Hz) aortic segments at an extended pressure range, while pharmacologically modulating VSMC tone and endothelial cell function. We found that the effects of α1‐adrenergic stimulation with phenylephrine on the pressure‐stiffness relationship varied in sensitivity, magnitude and direction, with the basal, unstimulated NO production by the endothelium playing a pivotal role. We also investigated how arterial disease affected this system by using the angiotensin‐II‐treated mouse. Our results show that isobaric stiffness was increased and that the aortic segments demonstrated a reduced capacity for modulating the pressure‐stiffness relationship. This suggests that not only increased isobaric stiffness at normal pressure, but also a reduced capacity of the VSMCs to limit the pressure‐associated increase in aortic stiffness, may contribute to the pathogenesis of this mouse model. Overall, this study provides more insight in how aortic VSMC tone affects the pressure‐dependency of aortic biomechanics at different physiological and pathological conditions.
机译：在过去的几十年中，对孤立的胸主动脉节段的等距收缩研究为我们对主动脉血管平滑肌细胞（VSMC）的主动，收缩特性及其与内皮细胞的串扰的整体理解做出了重要贡献。但是，目前尚不清楚VSMC在健康主动脉中收缩或舒张的生理作用及其对主动脉脉搏平滑能力的影响。因此，我们调查了VSMC收缩和松弛对健康小鼠主动脉同量异位生物力学特性的急性影响。在药理学上调节VSMC音调和内皮细胞功能时，使用内部开发的设置来测量周期性拉伸（10？Hz）主动脉段的等压刚度参数。我们发现，苯肾上腺素对α1-肾上腺素能刺激的压力-刚度关系在敏感性，幅度和方向上都有变化，内皮的基础性，非刺激性NO产生起关键作用。我们还通过使用血管紧张素II治疗的小鼠研究了动脉疾病如何影响该系统。我们的结果表明，等压刚度增加，主动脉段显示出降低压力-刚度关系的能力。这表明，不仅常压下的等压刚度增加，而且VSMC限制与主动脉僵硬的压力相关的压力增加的能力降低，也可能有助于此小鼠模型的发病。总的来说，这项研究提供了更多关于在不同生理和病理条件下主动脉VSMC音调如何影响主动脉生物力学的压力依赖性的见解。

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