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The impact of exercise training and resveratrol supplementation on gut microbiota composition in high‐fat diet fed mice

机译：运动训练和补充白藜芦醇对高脂饮食喂养小鼠肠道菌群组成的影响

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The aim of this study was to examine the effect of exercise training and dietary supplementation of resveratrol on the composition of gut microbiota and to test the hypothesis that exercise training and resveratrol can prevent high‐fat diet (HFD)‐induced changes in the gut microbiota. Mice fed a HFD supplemented with resveratrol (4?g/kg food) were protected against diet‐induced obesity, while exercise trained HFD‐fed animals (running on average 50?km/week) were not. Dietary resveratrol supplementation induced changes predominantly in the low‐abundant bacteria, while exercise training induced changes in the high‐abundant bacteria in the gut as analyzed by ADONIS test with Weighted UniFrac distances. Interestingly, the two interventions affected the gut microbiome independently of the inflammatory state of the HFD‐fed animals as assessed by the systemic serum amyloid A levels. These results suggest that both resveratrol supplementation and regular physical activity modulate the composition of murine microbiota independently of the systemic inflammatory state. Moreover, the effects of exercise training on the microbiota seem to occur without changes in adiposity, while resveratrol‐mediated alterations may relate to adipose tissue mass.
机译：这项研究的目的是检验运动训练和饮食补充白藜芦醇对肠道菌群组成的影响，并检验运动训练和白藜芦醇可以预防高脂饮食（HFD）引起的肠道菌群变化的假设。 。饲喂补充了白藜芦醇（4？g / kg食物）的HFD的小鼠可以防止饮食引起的肥胖，而接受运动训练的由HFD喂养的动物（平均每周跑50？km）则没有。饮食中白藜芦醇的添加主要导致低丰度细菌的变化，而运动训练则导致肠道中高丰度细菌的变化，这是通过ADONIS测试和加权UniFrac距离分析得出的。有趣的是，这两种干预措施均影响肠道微生物组，而不受HFD喂养动物的炎症状态影响（通过全身血清淀粉样蛋白A水平评估）。这些结果表明，补充白藜芦醇和有规律的体力活动均能独立于全身炎症状态来调节鼠类微生物的组成。此外，运动训练对微生物群的影响似乎在没有脂肪变化的情况下发生，而白藜芦醇介导的改变可能与脂肪组织量有关。

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