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首页> 外文期刊>PLoS Genetics >Aging Mice Show a Decreasing Correlation of Gene Expression within Genetic Modules
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Aging Mice Show a Decreasing Correlation of Gene Expression within Genetic Modules

机译：衰老小鼠显示遗传模块内基因表达的相关性下降

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In this work we present a method for the differential analysis of gene co-expression networks and apply this method to look for large-scale transcriptional changes in aging. We derived synonymous gene co-expression networks from AGEMAP expression data for 16-month-old and 24-month-old mice. We identified a number of functional gene groups that change co-expression with age. Among these changing groups we found a trend towards declining correlation with age. In particular, we identified a modular (as opposed to uniform) decline in general correlation with age. We identified potential transcriptional mechanisms that may aid in modular correlation decline. We found that computationally identified targets of the NF-ΚB transcription factor decrease expression correlation with age. Finally, we found that genes that are prone to declining co-expression tend to be co-located on the chromosome. Our results conclude that there is a modular decline in co-expression with age in mice. They also indicate that factors relating to both chromosome domains and specific transcription factors may contribute to the decline.
机译：在这项工作中，我们提出了一种用于基因共表达网络差异分析的方法，并将其应用于衰老过程中的大规模转录变化。我们从年龄为16个月和24个月大的小鼠的AGEMAP表达数据中获得了同义基因共表达网络。我们确定了许多功能基因组，它们会随着年龄的增长而改变共表达。在这些变化的群体中，我们发现与年龄的相关性呈下降趋势。特别是，我们确定了与年龄的总体相关性呈模块性下降（而非统一下降）。我们确定了可能有助于模块化相关性下降的潜在转录机制。我们发现，通过计算确定的NF-κB转录因子靶标降低了与年龄的表达相关性。最后，我们发现倾向于降低共表达的基因倾向于共定位在染色体上。我们的结果得出结论，小鼠中共表达随年龄呈模块化下降。他们还表明，与染色体结构域和特定转录因子相关的因素可能会导致这种下降。

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