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首页> 外文期刊>PLOS Neglected Tropical Diseases >Environmental enteric dysfunction pathways and child stunting: A systematic review
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Environmental enteric dysfunction pathways and child stunting: A systematic review

机译：环境性肠功能障碍途径和儿童发育迟缓：系统评价

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Author summary Globally, one-quarter of children under the age of five are affected by poor linear growth, known as stunting. Interventions, including giving children supplemental foods or improving hygiene to prevent diarrhea, have only been partially successful at restoring normal growth. Environmental enteric dysfunction (EED) is a disease characterized by damage to the lining of the small intestine and is thought to contribute to stunting, though the exact mechanism is still unclear. EED was first diagnosed by removing samples of the intestinal lining and analyzing them under a microscope; however, these procedures are costly and invasive, and recent research has focused on discovering easier ways to identify EED. These tests focus on the many interconnected aspects of EED, including damage and function of the intestinal wall, inflammation, and presence of pathogenic bacteria outside the gut. We conducted a systematic review to evaluate the evidence of relationships between each aspect of EED and stunting. We found the most evidence for the relationship between inflammation and stunting, but less evidence for the relationship between stunting and the presence of pathogenic bacteria outside the gut. Our results suggest that EED may be more complex than previously conceived and that some frequently used EED tests may need reconsideration.
机译：作者摘要在全球范围内，四分之一的五岁以下儿童受到线性发育不良（发育迟缓）的影响。干预措施，包括为儿童提供补充食品或改善卫生条件以防止腹泻，在恢复正常生长方面仅取得了部分成功。环境性肠功能障碍（EED）是一种以小肠内膜受损为特征的疾病，尽管其确切机制仍不清楚，但据认为可导致发育迟缓。首先通过去除肠壁样本并在显微镜下进行分析来诊断EED。然而，这些程序昂贵且具有侵入性，并且最近的研究集中在发现更简单的识别EED的方法。这些测试的重点是EED的许多相互联系的方面，包括肠壁的损伤和功能，炎症以及肠道外病原细菌的存在。我们进行了系统的评估，以评估EED与发育迟缓各个方面之间关系的证据。我们发现有关炎症和发育迟缓之间关系的证据最多，但有关发育迟缓和肠道外病原细菌存在之间关系的证据较少。我们的结果表明EED可能比以前设想的要复杂，并且一些经常使用的EED测试可能需要重新考虑。

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