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首页> 外文期刊>PLoS One >Meta-Analysis of Anti-Muscarinic Receptor Type 3 Antibodies for the Diagnosis of Sjögren Syndrome
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Meta-Analysis of Anti-Muscarinic Receptor Type 3 Antibodies for the Diagnosis of Sjögren Syndrome

机译：抗Muscarinic受体3型抗体的Sjögren综合征诊断的Meta分析

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Purpose To conduct a meta-analysis to evaluate the diagnostic value of anti-muscarinic receptor type 3 (M3R) antibodies in Sjögren syndrome (SS). Methods Two databases, PUBMED and the Cochrane Library, were systematically searched. Approximately 2,000 participants from several studies were included in this research. STATA 11.2 software and Meta-DiSc 1.4 was used to conduct the meta-analysis. Results Eleven studies were included in the meta-analysis. The pooled DOR was 13.00 (95% CI, 6.00–26.00). The sensitivity was 0.43 (95% CI, 0.28–0.58) and the specificity was 0.95 (95%CI, 0.91–0.97). The LR+ and LR- were 7.90 (95% CI, 4.70–13.40), 0.61 (95% CI, 0.46–0.79), respectively. The AUC was 0.89 (95% CI, 0.86–0.92). Conclusion The anti-M3R antibody had high specificity but relatively low sensitivity for the diagnosis of SS.
机译：目的进行荟萃分析，以评估抗毒蕈碱受体3型（M3R）抗体在Sjögren综合征（SS）中的诊断价值。方法系统搜索两个数据库，即PUBMED数据库和Cochrane库。这项研究包括来自几项研究的大约2,000名参与者。使用STATA 11.2软件和Meta-DiSc 1.4进行荟萃分析。结果荟萃分析共纳入11项研究。合并的DOR为13.00（95％CI，6.00-26.00）。灵敏度为0.43（95％CI，0.28-0.58），特异性为0.95（95％CI，0.91-0.97）。 LR +和LR-分别为7.90（95％CI，4.70-13.40），0.61（95％CI，0.46-0.79）。 AUC为0.89（95％CI，0.86-0.92）。结论抗M3R抗体对SS的诊断特异性高，但敏感性较低。

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