Dual RNA-seq of Parasite and Host Reveals Gene Expression Dynamics during Filarial Worm–Mosquito Interactions

Young-Jun Choi; Matthew T. Aliota; George F. Mayhew; Sara M. Erickson; Bruce M. Christensen

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Dual RNA-seq of Parasite and Host Reveals Gene Expression Dynamics during Filarial Worm–Mosquito Interactions

机译：寄生虫和宿主的双重RNA序列揭示了丝虫-蚊子相互作用期间的基因表达动力学。

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Background Parasite biology, by its very nature, cannot be understood without integrating it with that of the host, nor can the host response be adequately explained without considering the activity of the parasite. However, due to experimental limitations, molecular studies of parasite-host systems have been predominantly one-sided investigations focusing on either of the partners involved. Here, we conducted a dual RNA-seq time course analysis of filarial worm parasite and host mosquito to better understand the parasite processes underlying development in and interaction with the host tissue, from the establishment of infection to the development of infective-stage larva.

机译：背景技术从本质上讲，如果不将其与宿主的生物学相结合就无法理解其生物学特性，而在不考虑该寄生虫的活性的情况下也无法充分解释宿主的反应。然而，由于实验的局限性，寄生虫宿主系统的分子研究主要是侧重于涉及的任何一个伙伴的单方面研究。在这里，我们对丝虫寄生虫和宿主蚊虫进行了双重RNA-seq时程分析，以更好地了解从感染的建立到感染期幼虫的发育，宿主组织中潜在的寄生虫过程以及与宿主组织的相互作用。

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《PLOS Neglected Tropical Diseases》 |2014年第5期|共13页
作者
Young-Jun Choi; Matthew T. Aliota; George F. Mayhew; Sara M. Erickson; Bruce M. Christensen;
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中图分类传染病;
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1. Integrated dual RNA-seq and dual iTRAQ of infected tissue reveals the functions of a diguanylate cyclase gene of Pseudomonas plecoglossicida in host-pathogen interactions with Epinephelus coioides [J] . Luo Gang, Zhao Lingmin, Xu Xiaojin, Fish & Shellfish Immunology . 2019,第期

机译：综合的双RNA-SEQ和受感染组织的双ITRAQ揭示了与EPINEPHELUS COIIAIDE的宿主病原体相互作用的Pseudomonaspocoglossica的Diguantylys Cycoglossica的功能
2. Global Gene Expression Analysis of the Zoonotic Parasite Trichinella spiralis Revealed Novel Genes in Host Parasite Interaction [J] . Xiaolei Liu, Yanxia Song, Ning Jiang, PLOS Neglected Tropical Diseases . 2012,第8期

机译：人畜共患寄生虫旋毛虫的全球基因表达分析揭示了宿主寄生虫相互作用中的新基因。
3. Dual RNA-Seq reveals the role of a transcriptional regulator gene in pathogen-host interactions between Pseudomonas plecoglossicida and Epinephelus coioides [J] . Zhang Beibei, Zhuang Zhixia, Wang Xiaoru, Fish & Shellfish Immunology . 2019,第期

机译：双RNA-SEQ揭示转录调节剂基因在假单胞菌（Pheinoglossicida和Epinephelus Coioides）之间的病原体 - 宿主相互作用中的作用
4. Vector-parasite Molecular Interactions: Malarial Molecules Essential for Parasite Invasion into the Host Mosquito Tissues [C] . Y. Chinze International Congress of Parasitology . 2006

机译：载体寄生虫分子相互作用：寄生虫侵入到主体蚊子组织必需的疟原虫分子
5. Mechanisms of communication in the filarial worm, Brugia malayi, at the mosquito vector-mammalian host interface. [D] . Fraser, Lisa M. 2016

机译：丝虫-哺乳动物宿主界面中丝虫蠕虫马来亚的传播机制。
6. Dual RNA-seq of Parasite and Host Reveals Gene Expression Dynamics during Filarial Worm–Mosquito Interactions [O] . Young-Jun Choi, Matthew T. Aliota, George F. Mayhew, 2014

机译：寄生虫和宿主的双重RNA序列揭示了丝虫-蚊子相互作用期间的基因表达动力学。
7. Dual RNA-seq of parasite and host reveals gene expression dynamics during filarial worm–mosquito interactions [O] . Choi Young-Jun, Aliota Matthew T, Mayhew George F, 2014

机译：寄生虫和宿主的双重RNA-seq揭示了丝虫-蚊子相互作用过程中的基因表达动态
8. Gene Expression Profiling of Monkeypox Virus-Infected Cells Reveals Novel Interfaces for Host-Virus Interactions [R] . Alkhalil, A., Hammamieh, R., Hardick, J., 2010

机译：猴痘病毒感染细胞的基因表达谱分析揭示了宿主 - 病毒相互作用的新界面

Dual RNA-seq of Parasite and Host Reveals Gene Expression Dynamics during Filarial Worm–Mosquito Interactions

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