...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Polish Archives of Internal Medicine >Subclinical organ damage in perimenopausal women with essential hypertension
【24h】

Subclinical organ damage in perimenopausal women with essential hypertension

机译：绝经后妇女原发性高血压的亚临床器官损伤

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

INTRODUCTION: Hypertension and its complications are more common in postmenopausal women than before menopause. However, whether this is due to the effect of age or menopause is still unknown. OBJECTIVES: The aim of the study was to assess the effect of menopause on blood pressure (BP), left ventricular and vascular structure and function, as well as kidney function in perimenopausal women. PATIENTS AND METHODS: The study involved 192 women aged 40 to 60 years (mean age, 51.73 ±1.82 years), including 152 with newly diagnosed essential hypertension and 40 normotensive controls matched for age. In all subjects, 24-hour BP monitoring was performed. Echocardiographic examination with the assessment of left ventricular mass (LVM) and systolic and diastolic function,as well as carotid ultrasound with the measurement of intima-media thickness (IMT) in the common carotid artery were performed. Carotid-femoral pulse wave velocity (PWV) was measured. Glomerular filtration rate (eGFR) was calculated and urinary albumin-creatinine ratio (UACR) was measured. RESULTS: The study group was divided according to hypertension and menopausal status into 4 subgroups: normotensive premenopausal, normotensive postmenopausal, hypertensive premenopausal, and hypertensive postmenopausal women. Menopause did not affect BP or LVM. Differences in LVM between pre- and postmenopausal women were dependent on age and the body mass index. Hypertensive postmenopausal compared with hypertensive premenopausal women had significantly higher IMT (0.72 ±0.34 mm vs. 0.59 ±0.30 mm, P = 0.001) and a lower ratio of early to late mitral inflow velocity (E/A, 1.04 ±0.32 vs. 1.32 ±0.33, P = 0.01). PWV was higher in hypertensives compared to controls (9.7 ±1.6 m/s vs. 8.4 ±1.2 m/s, P = 0.001), without differences between premenopausal and postmenopausal women. Menopause did not affect eGFR and UACR either in the hypertensive or normotensive group. CONCLUSIONS: Left ventricular diastolic function and carotid IMT are independently associated with menopausal status in both normo- and hypertensive women. Menopause per se did not affect BP in the examined group.
机译：简介：绝经后女性比绝经前更常见高血压及其并发症。但是，这是由于年龄还是更年期的影响仍然未知。目的：本研究旨在评估更年期妇女对绝经对血压，左心室和血管结构与功能以及肾功能的影响。患者与方法：该研究纳入了192位40至60岁（平均年龄51.73±1.82岁）的妇女，其中152名新诊断为原发性高血压和40名与年龄相匹配的血压正常对照。在所有受试者中，均进行24小时BP监测。进行超声心动图检查，评估左心室质量（LVM）和收缩和舒张功能，并进行颈动脉超声检查，并测量颈总动脉内膜中膜厚度（IMT）。测量颈股脉搏波速度（PWV）。计算肾小球滤过率（eGFR）并测量尿白蛋白-肌酐比值（UACR）。结果：研究组根据高血压和绝经状态分为四个亚组：正常血压的绝经前，正常血压的绝经后，高血压的绝经前和高血压的绝经后妇女。更年期不影响BP或LVM。绝经前后妇女的LVM差异取决于年龄和体重指数。与高血压绝经前女性相比，高血压绝经后女性的IMT显着更高（0.72±0.34 mm vs. 0.59±0.30 mm，P = 0.001），早期和晚期二尖瓣血流速度的比率较低（E / A，1.04±0.32 vs. 1.32± 0.33，P = 0.01）。高血压患者的PWV高于对照组（9.7±1.6 m / s与8.4±1.2 m / s，P = 0.001），绝经前和绝经后妇女之间无差异。在高血压或血压正常的人群中，更年期均不影响eGFR和UACR。结论：正常和高血压妇女的左室舒张功能和颈动脉IMT与绝经状态独立相关。在研究组中，更年期本身并不影响血压。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号