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Reference values for serum levels of vitamin B12 and folic acid in a population-based sample of adults between 35 and 80 years of age

机译：35岁至80岁成年人口人群中维生素B12和叶酸血清水平的参考值

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Objectives:To examine folic acid and vitamin B12 status in a group of 1000 persons sampled from the community of Ume?￥, Sweden, and aged 35, 40, 45, 50, 55, 60, 65, 70, 75 or 80 years. Reference data for folate and age-stratified reference data for vitamin B12 are presented, together with an examination of potential confounders.Measurements:All subjects participated in extensive health examinations and interviews, and laboratory blood testing was performed.Results:A series of exclusion criteria were applied, and data from 961 subjects were analysed. Vitamin B12 levels were found to decrease with increasing age, whereas folate levels remained constant across the age span studied. None of the vitamins was found to vary with sex, education, smoking or alcohol consumption, body mass index, prescription-free vitamin supplements, level of haemoglobin, or mean cell volume of erythrocytes. Further, none of these factors was associated with the age-related decrease of vitamin B12 level.Conclusions:The offered reference ranges should be used only in order to rule out deficiency. For B12 levels, the age of the subject should be considered such that, for elderly people in particular, values above the medians should be considered as indicative of normal vitamin status.
机译：目的：从瑞典的Ume？￥社区抽取1000名年龄分别为35岁，40岁，45岁，45岁，50岁，55岁，60岁，65岁，70岁，75岁或80岁的1000人作为研究对象，调查叶酸和维生素B12的状况。提供叶酸的参考数据和维生素B12的年龄分层参考数据，并检查潜在的混杂因素测量：所有受试者均参加了广泛的健康检查和访谈，并进行了实验室血液测试结果：一系列排除标准应用了961位受试者的数据，并对其进行了分析。发现维生素B12水平随着年龄的增长而降低，而叶酸水平在所研究的整个年龄段中保持恒定。没有发现任何一种维生素随性别，教育程度，吸烟或饮酒，体重指数，无处方维生素补充剂，血红蛋白水平或红细胞平均细胞量而变化。此外，这些因素均与年龄相关的维生素B12水平下降无关。结论：提供的参考范围仅应用于排除缺乏症。对于B12水平，应考虑受试者的年龄，尤其是对于老年人，高于中位数的值应视为正常维生素状态的指示。

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