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Multivitamin supplement use and risk of invasive breast cancer

机译：多种维生素补充剂的使用和浸润性乳腺癌的风险

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ObjectiveMultivitamin supplements are used by nearly half of middle-aged women in the USA. Despite this high prevalence of multivitamin use, little is known about the effects of multivitamins on health outcomes, including cancer risk. Our main objective was to determine the association between multivitamin use and the risk of breast cancer in women.DesignWe conducted a population-based casea€“control study among 2968 incident breast cancer cases (aged 20a€“69 years), diagnosed between 2004 and 2007, and 2982 control women from Wisconsin, USA. All participants completed a structured telephone interview which ascertained supplement use prior to diagnosis, demographics and risk factor information. Odds ratios and 95 % confidence intervals were calculated using multivariable logistic regression.ResultsCompared with never users of multivitamins, the OR for breast cancer was 1?·02 (95 % CI 0?·87, 1?·19) for current users and 0?·99 (95 % CI 0?·74, 1?·33) for former users. Further, neither duration of use (for a‰￥10 years: OR = 1?·13, 95 % CI 0?·93, 1?·38, P for trend = 0?·25) nor frequency (>7 times/week: OR = 1?·00, 95 % CI 0?·77, 1?·28, P for trend = 0?·97) was related to risk in current users. Stratification by menopausal status, family history of breast cancer, age, alcohol, tumour staging and postmenopausal hormone use did not significantly modify the association between multivitamin use and breast cancer.ConclusionsThe current study found no association between multivitamin supplement use and breast cancer risk in women.
机译：在美国，近一半的中年女性都使用多种维生素补充剂。尽管使用多种维生素的流行率很高，但对于多种维生素对健康结果（包括癌症风险）的影响知之甚少。我们的主要目标是确定女性服用多种维生素与乳腺癌风险之间的关联。设计我们在2004年至2004年之间诊断的2968例乳腺癌（年龄在20岁至69岁之间）病例中进行了基于人群的病例对照研究。 2007年，来自美国威斯康星州的2982名控制妇女。所有参与者完成了结构化的电话采访，在诊断，人口统计和风险因素信息之前确定补充剂的使用。结果使用多变量logistic回归计算赔率和95％置信区间。结果与从未使用多种维生素的人相比，乳腺癌的OR为1？·02（95％CI 0？·87，1？·19），0为以前的用户为？·99（95％CI 0？·74，1？·33）。此外，使用期限（≥￥ 10年：OR = 1？·13，95％CI 0？·93，1？·38，趋势的P = 0？·25）或频率（> 7次/周：OR = 1？00，95％CI 0？77，1？28，趋势P = 0？97的P）与当前用户的风险有关。按更年期状态，乳腺癌家族史，年龄，酒精，肿瘤分期和绝经后激素使用进行分层并没有显着改变复合维生素的使用与乳腺癌之间的联系。结论当前的研究发现，复合维生素的使用与女性乳腺癌风险之间没有关联。 。

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