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A preliminary study of the genes related to aggression and insensitivity to pain in autism spectrum disorders

机译：对自闭症谱系障碍的侵略性和对疼痛不敏感相关基因的初步研究

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Objective: Autism spectrum disorders (ASDs) is a heterogeneous neuropsychiatric disorder with widespread abnormalities of social interaction and communication, showing severely restricted interests and extreme repetitive behavior. The relationship between aggressive behavior, insensitivity to pain, and ASDs could not be explained completely. Therefore, we aimed to contribute to the etiology by examining the gene expressions of OPRL1 , TACR1 , and HTR1E in patients with ASDs.Methods: This study was held in the Genome and Stem Cell Research Center of Erciyes University. In this present study, the expressions of OPRL1 , TACR1 , and HTR1E genes were studied in 22 ASD patients and 14 healthy controls. Quantitative Real-time Polymerase Chain Reaction (qRT-PCR) was used for gene expression studies.Results: There was a statistically significant difference in terms of the expression of the three genes, which we examined between the ASD patient and control groups. Positive and strong correlations were obtained between the three gene expressions in the ASD group and this finding was found to be statistically significant.Conclusions: Considering all these findings, large-scale and new researches are needed for revealing the roles of genes and their pathways which are related to aggression and insensitivity to pain in ASDs. Our results will lead to new research studies in this field.
机译：目的：自闭症谱系障碍（ASDs）是一种异质性神经精神障碍，具有广泛的社交互动和交流异常，表现出严格的兴趣限制和极端的重复性行为。攻击行为，对疼痛不敏感和自闭症之间的关系无法完全解释。因此，我们的目的是通过检查ASD患者的 OPRL1， TACR1和 HTR1E的基因表达，为病因做出贡献。方法：本研究在美国疾病预防控制中心基因组和干细胞研究中心进行。埃尔西耶斯大学。在本研究中，在22例ASD患者和14例健康对照中研究了OPRL1，TACR1和HTR1E基因的表达。结果：我们在ASD患者和对照组之间检查了这三个基因的表达，在统计学上有显着性差异。我们使用定量实时聚合酶链反应（qRT-PCR）进行基因表达研究。结论：考虑到所有这些发现，需要进行大规模和新的研究来揭示基因的作用及其途径，这在ASD组的三个基因表达之间具有正相关和强相关性，并且这一发现具有统计学意义。与ASD的攻击性和对疼痛不敏感有关。我们的结果将导致该领域的新研究。

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