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首页> 外文期刊>Pulmonary Circulation >Pentraxin-3 and the Right Ventricle: The Multi-Ethnic Study of Atherosclerosis–Right Ventricle Study:
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Pentraxin-3 and the Right Ventricle: The Multi-Ethnic Study of Atherosclerosis–Right Ventricle Study:

机译：Pentraxin-3和右心室：动脉粥样硬化的多民族研究-右心室研究：

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Pentraxin-3 (PTX3) is a protein mediator of innate immunity that is elevated in the setting of left heart disease and pulmonary arterial hypertension. The relationship between PTX3 and right ventricular (RV) structure and function is not known. We included men and women with magnetic resonance imaging assessment of RV structure and function and measurement of PTX3 from the Multi-Ethnic Study of Atherosclerosis, a study of individuals free of clinical cardiovascular disease. Multivariable linear regression estimated associations between PTX3 protein levels and RV measures after adjusting for demographic characteristics, anthropometrics, smoking status, diabetes mellitus, hypertension, and corresponding left ventricular (LV) parameters. Instrumental variable analysis exploiting Mendelian randomization was attempted using two-stage least squares regression. The study sample included 1,779 participants with available PTX3 levels, RV measures, and all covariables. Mean PTX3 level was 2.1 ng/mL. Higher PTX3 was independently associated with greater RV mass and larger RV end-diastolic volume with and without adjustment for the corresponding LV parameters or C-reactive protein (all P .05). There was no association between PTX3 and RV ejection fraction or stroke volume. Single-nucleotide polymorphisms were not associated with PTX3 protein levels or RV measures after accounting for race. Instrumental variable analysis could not be reliably performed. Higher PTX3 protein levels were associated with greater RV mass and larger RV end-diastolic volume. These associations were independent of common cardiovascular risk factors and LV morphologic changes. Inflammation is associated with differences in the pulmonary circulation-RV axis in adults without clinical cardiovascular disease.
机译：Pentraxin-3（PTX3）是先天免疫的蛋白质介质，在左心疾病和肺动脉高压的情况下会升高。 PTX3与右心室（RV）结构和功能之间的关系未知。我们对男性和女性进行了磁共振成像评估，评估了RV的结构和功能，并从多族裔动脉粥样硬化研究中对PTX3进行了测量，这项研究是针对无临床心血管疾病的个体进行的研究。在调整了人口统计学特征，人体测量学，吸烟状况，糖尿病，高血压和相应的左心室（LV）参数后，多变量线性回归估计了PTX3蛋白水平与RV值之间的关联。使用两阶段最小二乘回归尝试利用孟德尔随机进行工具变量分析。该研究样本包括1,779名参与者，这些参与者具有可用的PTX3水平，RV量度和所有协变量。 PTX3平均水平为2.1 ng / mL。较高的PTX3独立地与较大的RV质量和较大的RV舒张末期容积相关，而无需调整相应的LV参数或C反应蛋白（所有P <.05）。 PTX3与RV射血分数或每搏量之间无关联。考虑种族后，单核苷酸多态性与PTX3蛋白水平或RV测量值无关。工具变量分析无法可靠地执行。 PTX3蛋白水平越高，RV质量越高，RV舒张末期容积越大。这些关联独立于常见的心血管危险因素和左室形态变化。没有临床心血管疾病的成年人，炎症与肺循环-RV轴的差异有关。

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