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首页> 外文期刊>Pulmonary therapy. >In-Vitro Characterization of the Aerosolized Dose During Non-Invasive Automatic Continuous Positive Airway Pressure Ventilation
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In-Vitro Characterization of the Aerosolized Dose During Non-Invasive Automatic Continuous Positive Airway Pressure Ventilation

机译：无创自动连续正气道正压通气期间雾化剂量的体外表征

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Introduction Many devices (e.g., nebulizers and spacers) are used to deliver aerosol in a non-invasive ventilation circuit (NIV) without any special recommendation. The aim of the present work was to compare the doses delivered from seven different aerosol delivery systems when placed in the NIV using automatic continuous positive airway pressure (Auto-CPAP). Methods Three spacers and three vibrating mesh nebulizers were compared to a Sidestream jet nebulizer (SIDE). Each device was placed proximal to a breathing simulator in a standard NIV circuit with a 500?ml tidal volume, 15?breaths/min and a 1:3 inspiratory-expiratory ratio. Two ml of salbutamol solution containing 10,000?μg was nebulized using Aerogen Pro (PRO), Aerogen Solo (SOLO), NIVO and SIDE. Twelve metered dose inhaler doses, containing 100?μg salbutamol each, were delivered using AeroChamber MV (AC), AeroChamber Vent (VC) and AeroChamber Mini (MC). Total emitted dose (TED) and its percentage were determined. Aerodynamic droplet characteristics were measured using cooled Andersen Cascade Impactor. Results The vibrating mesh nebulizers used had significantly more ( p Conclusions Aerosol delivery in Auto-CPAP NIV is feasible; however, aerosol delivery method should be chosen or substituted with care. 2?mg delivered from a spacer would be equivalent to 3?mg nebulized from a vibrating mesh nebulizer and 5?mg nebulized from a Sidestream.
机译：简介许多设备（例如雾化器和间隔器）用于在无创通气回路（NIV）中输送气雾剂，无特殊建议。本工作的目的是比较使用自动连续气道正压通气（Auto-CPAP）放置在NIV中时从七个不同的气雾剂输送系统输送的剂量。方法将三个垫片和三个振动筛网雾化器与Sidestream喷射雾化器（SIDE）进行比较。将每个设备放在标准NIV回路中呼吸模拟器的近端，潮气量为500毫升/分钟，呼吸频率为15毫升/分钟，吸气-呼气比为1：3。使用Aerogen Pro（PRO），Aerogen Solo（SOLO），NIVO和SIDE雾化两毫升含有10,000？g的沙丁胺醇溶液。使用AeroChamber MV（AC），AeroChamber Vent（VC）和AeroChamber Mini（MC）递送十二种计量吸入器剂量，每种剂量吸入100μg沙丁胺醇。确定总发射剂量（TED）及其百分比。使用冷却的Andersen级联撞击器测量空气动力学液滴特性。结果使用的振动筛网雾化器具有更多功能（p结论Auto-CPAP NIV中的气雾剂输送是可行的;但是，应选择或谨慎地使用气雾剂输送方法。从隔离器中输送2mg相当于雾化3μg从振动筛网雾化器中提取，再从Sidestream雾化5mg。

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