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首页> 外文期刊>Ukrainian Biochemical Journal >Pro-/antioxidant reactions and nitrogen oxide metabolism under sub-chronic effect of succinic acid derivatives
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Pro-/antioxidant reactions and nitrogen oxide metabolism under sub-chronic effect of succinic acid derivatives

机译：琥珀酸衍生物亚慢性作用下的前/抗氧化剂反应和氮氧化物代谢

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The derivatives of a succinic acid represent active compounds which realize their biological action via the influence on pro-/antioxidant processes and energetic metabolism. We studied the nitrogen oxide metabolism as well as reactions of the proteins and lipids free-radical peroxide oxidation under a sub-chronic effect of anti-diabetically active compounds – succinic acid derivatives and its metabolites. We found that the studied compounds were able to change the intensity of protein- and lipoperoxidation in a liver and blood serum interconnected with changes in the activity of the key antioxidant enzymes. The derivatives of succinic acid proved to inhibit the nitrogen oxide synthase reflected in a decrease in nitrite- and nitrate-anion level in a liver, blood plasma and urine as well as in changes in the oxidation processes in a liver and blood serum. We concluded in stating that the specified changes of pro-/antioxidant and nitrogen oxide homeostasis may serve as assessment criteria of the succinate-containing compounds’ biological action.
机译：琥珀酸的衍生物代表活性化合物，其通过对前/抗氧化剂过程和能量代谢的影响来实现其生物学作用。我们研究了抗糖尿病活性化合物（琥珀酸衍生物及其代谢物）在亚慢性作用下的氮氧化物代谢以及蛋白质和脂质自由基过氧化物的氧化反应。我们发现，所研究的化合物能够改变与主要抗氧化酶活性相关的肝脏和血清中蛋白质和脂过氧化的强度。事实证明，琥珀酸的衍生物可以抑制氮氧化物合酶，这反映在肝脏，血浆和尿液中亚硝酸盐和硝酸盐阴离子水平的降低以及肝脏和血清中氧化过程的变化中。我们的结论是，前/抗氧化剂和氮氧化物稳态的特定变化可作为评估含琥珀酸酯化合物生物活性的标准。

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