...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Ukrainian Biochemical Journal >Effects of L-glutamic acid and pyridoxine on glutathione depletion and lipid peroxidation generated by epinephrine-induced stress in rats
【24h】

Effects of L-glutamic acid and pyridoxine on glutathione depletion and lipid peroxidation generated by epinephrine-induced stress in rats

机译：L-谷氨酸和吡ido醇对肾上腺素诱导的应激引起的谷胱甘肽耗竭和脂质过氧化的影响

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The main goal of this research was to investigate and compare the protective effects of L-glutamic acid (L-Glu) alone and combined with Pyridoxine (L-Glu+Pyridoxine) for the purpose of suppression and mitigation of epinephrine-induced stress in rats. This study outlines possible links between changes of reduced glutathione (GSH) level, antioxidant enzymes activity and content of the lipid peroxidation products after administration of the above-mentioned substances and under the action of stress in various tissues of rats. The obtained results suggest that the GSH level was significantly inhibited by stress in all investigated tissues (except kidneys). We have shown that under the stress, activities of glutathione-associated enzymes were changed (mainly decreased) in all investigated tissues. In rats, additionally received L-Glu and L-Glu+Pyridoxine, much less changes or lack of changes in studied parameters were observed. The content of lipid peroxidation products (lipid peroxides (LOOH) and thiobarbituric acid reactive substances (TBARS)) in myocardium, liver and kidney tissues of experimental groups under the stress conditions were significantly higher compared to the control. While in experimental groups that received L-Glu and L-Glu+Pyridoxine LOOH content in kidney, spleen and liver and TBARS content in spleen, liver and myocardium were almost at the level of control values. These results indicate that L-Glu and L-Glu+Pyridoxine can mitigate and suppress epinephrine-induced stress in rats.
机译：这项研究的主要目的是研究和比较单独使用L-谷氨酸（L-Glu）并与吡y醇（L-Glu + Pyridoxine）组合的保护作用，目的是抑制和减轻肾上腺素引起的大鼠应激。这项研究概述了谷胱甘肽（GSH）含量降低，抗氧化酶活性变化与脂质过氧化产物含量的变化之间的可能联系，这些物质在上述物质给药后和在大鼠各种组织的应激作用下均存在。获得的结果表明，所有研究的组织（肾脏除外）中的应激均显着抑制了GSH的水平。我们已经表明，在压力下，所有研究的组织中谷胱甘肽相关酶的活性都发生了变化（主要是下降）。在大鼠中，还接受了L-Glu和L-Glu +吡ox醇，观察到的参数变化很少​​或没有变化。在应激条件下，实验组的心肌，肝脏和肾脏组织中脂质过氧化产物（脂质过氧化物（LOOH）和硫代巴比妥酸反应性物质（TBARS））的含量均明显高于对照组。在实验组中，肾脏，脾脏和肝脏中的L-Glu和L-Glu +吡kidney醇的LOOH含量以及脾脏，肝脏和心肌中的TBARS含量几乎处于对照水平。这些结果表明，L-Glu和L-Glu +吡ox醇可以减轻和抑制肾上腺素引起的应激。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号