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首页> 外文期刊>Ukrainian Biochemical Journal >The role of resistin in the genesis of metabolic disorders in pathological pregnancy
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The role of resistin in the genesis of metabolic disorders in pathological pregnancy

机译：抵抗素在病理性妊娠中代谢异常发生中的作用

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Pathological gestational weight gain (GWG) is a risk factor for obstetric and perinatal complications. High metabolic activity of adipose tissue and the placenta during pregnancy manifests as an increased production of adipokines that are involved in glucose regulation and insulin sensitivity. The aim of this study was to determine the role of resistin in the genesis of metabolic disorders in pathological GWG pregnancies. The 163 pregnant women were examined in the study: 97 (59.5%) had normal, 18 (11.0%) had insufficient and 48 (29.4%) had excessive prepregnancy weight and obesity. GWG was the recommended level in 56 (34.4%), insufficient in 33 (20.2%), and excessive in 74 (45.4%) women. Anthropometry was performed in each trimester of pregnancy, the weight gain was measured, and the percentage of body fat mass, concentrations of resistin, glucose, insulin, and the HOMA-IR were evaluated. Positive associations were found between hyperresistinemia in the second trimester of pregnancy, and subsequent weight gain ( r = 0.27, P = 0.0006), percentage of body fat mass ( r = 0.93, P = 0.000) and insulin resistance ( r = 0.89, P = 0.000) in late pregnancy; these associations were especially evident in excessive GWG. Determination of predictors of insulin resistance, associated with endocrine activity of adipose tissue, such as the adipokine resistin, in the second trimester of pregnancy may help to predict the severity of metabolic shifts during pregnancy and the risk of developing obstetric and perinatal complications.
机译：病理性妊娠体重增加（GWG）是产科和围产期并发症的危险因素。妊娠期间脂肪组织和胎盘的高代谢活性表现为与葡萄糖调节和胰岛素敏感性有关的脂肪因子的产生增加。这项研究的目的是确定抵抗素在病理性GWG妊娠中代谢紊乱的发生中的作用。在研究中检查了163名孕妇：97名（59.5％）正常，18名（11.0％）体重不足，48名（29.4％）体重和肥胖过多。 GWG是推荐的水平，为56（34.4％），不足的是33（20.2％），而过多的是74（45.4％）妇女。在怀孕的每个三个月进行人体测量，测量体重增加，并评估体脂质量百分比，抵抗素，葡萄糖，胰岛素和HOMA-IR的浓度。妊娠中期高脂血症与随后的体重增加（r = 0.27，P = 0.0006），体脂质量百分比（r = 0.93，P = 0.000）和胰岛素抵抗（r = 0.89，P）之间存在正相关关系= 0.000）孕晚期;这些关联在过多的GWG中尤为明显。在妊娠中期，确定胰岛素抵抗的预测因子与脂肪组织的内分泌活性（如脂肪因子抵抗素）有关，可能有助于预测妊娠期间代谢转移的严重程度以及发生产科和围产期并发症的风险。

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