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首页> 外文期刊>Ukrainian Biochemical Journal >Avidity of bivalent antibodies. Problems of its experimental determination and theoretical evaluation
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Avidity of bivalent antibodies. Problems of its experimental determination and theoretical evaluation

机译：二价抗体的亲和力。实验确定和理论评价的问题

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Some problems of experimental determination or theoretical evaluation of antibody avidity are considered. It was shown that in order to determine the fraction of nonoccupied antibodies in their mixture with the excess of the corresponding antigen which is required to estimate avidity the methods should be used which are more sensitive than ELISA. The available methods did not allow determining the avidity of bivalent antibodies because of many reasons. However, in the recent years new methods were suggested that make it possible to evaluate the avidity of bivalent antibodies and that of the receptors which consist of two binding sites connected by a flexible linker of the known length. Thus, there are all possibilities now for determining the avidity of bivalent antibodies in experiments or by theoretical methods.
机译：考虑了一些实验确定或抗体亲和力理论评估的问题。结果表明，为了确定抗体混合物中未占用抗体的比例以及估计抗原性所需的过量相应抗原，应使用比ELISA更灵敏的方法。由于许多原因，可用的方法不允许确定二价抗体的亲和力。然而，近年来，提出了新的方法，其使得有可能评估二价抗体的亲和力和由由已知长度的柔性接头连接的两个结合位点组成的受体的亲和力。因此，现在存在通过实验或通过理论方法确定二价抗体的亲和力的所有可能性。

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