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Polysaccharide-Based Hydrogels: The Key Role of Water in Affecting Mechanical Properties

机译：多糖基水凝胶：水在影响机械性能中的关键作用

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Different hydrogels were prepared starting from natural or semi-synthetic polysaccharides (carboxymethylcellulose, hyaluronic acid and chitosan) which were cross-linked by the addition of a cross-linking agent chosen according to the chemical groups present along the polymer chains. The cross-linking reaction allows for the formation of a three-dimensional network made of covalent bonds between the polymer chains, which is stable under physiological conditions. The presence of a substantial amount of water within the polysaccharide matrices makes such systems unique among hydrophilic gels. Water itself is responsible for some of their peculiar characteristics, one of which is their injectability which makes these hydrogels suitable for using as matrices for mini-invasive surgery and localized therapy.
机译：从天然或半合成多糖（羧甲基纤维素，透明质酸和壳聚糖）开始制备不同的水凝胶，这些多糖通过添加根据聚合物链上存在的化学基团选择的交联剂进行交联。交联反应允许在聚合物链之间形成由共价键构成的三维网络，该网络在生理条件下稳定。多糖基质中大量水的存在使此类系统在亲水性凝胶中独树一帜。水本身是造成其某些特殊特性的原因之一，其中之一就是其可注射性，这使得这些水凝胶适合用作微创手术和局部治疗的基质。

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