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首页> 外文期刊>Technology in cancer research & treatment. >The Ability of Prostate Health Index (PHI) to Predict Gleason Score in Patients With Prostate Cancer and Discriminate Patients Between Gleason Score 6 and Gleason Score Higher Than 6—A Study on 320 Patients After Radical Prostatectomy
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The Ability of Prostate Health Index (PHI) to Predict Gleason Score in Patients With Prostate Cancer and Discriminate Patients Between Gleason Score 6 and Gleason Score Higher Than 6—A Study on 320 Patients After Radical Prostatectomy

机译：前列腺健康指数（PHI）预测前列腺癌患者的Gleason评分的能力以及区分Gleason评分6和Gleason评分高于6的患者的能力-320例前列腺癌根治术后患者的研究

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The purpose of this study was to investigate the Prostate Health Index as a marker for tumor aggressiveness in prostate biopsy and the optimization of indication for treatment options. Our cohort consisted of 320 patients indicated for radical prostatectomy with preoperative measurements of total prostate-specific antigen, free prostate-specific antigen, [-2]proPSA, calculated %freePSA, and Prostate Health Index. The Gleason score was determined during biopsy and after radical prostatectomy. Using the Gleason score, we divided the group of patients into the 2 subgroups: Gleason score ≤6 and Gleason score >6. This division was performed according to the biopsy Gleason score and according to the postoperative Gleason score. We compared total prostate-specific antigen, [-2]proPSA, %freePSA, and Prostate Health Index in the subgroups Gleason score ≤6 and Gleason score >6 after biopsy and the definitive score. On evaluation of the subgroups created by Gleason score ≤6 and Gleason score >6, we observed agreement between biopsy Gleason score and definitive Gleason score in only 45.3% of cases. Of the calculated biopsy, Gleason score ≤6 and Gleason score >6 subgroups, [-2]proPSA, and Prostate Health Index (P = .0003 and P = .0005) were statistically significant. Of the definitive Gleason score ≤6 and Gleason score >6 subgroups, Prostate Health Index, [-2]proPSA, %freePSA, and PSA (P P P = .0003, and P = .0043) were statistically significant. The best area under the curve value (0.7496) was achieved by Prostate Health Index when the subgroups were established according to the postoperative Gleason score. Prostate Health Index is the best of the tested markers for the categorization of Gleason score 6 tumors and for facilitating the management of patients with prostate cancer. Prostate Health Index can be a helpful marker for indication of active surveillance or radical prostatectomy. Prostate health index can also simplify the decision of whether to perform nerve-sparing radical prostatectomy.
机译：这项研究的目的是研究前列腺健康指数，作为前列腺活检中肿瘤侵袭性的标志物，并优化治疗选择的适应症。我们的研究对象包括320名接受根治性前列腺切除术的患者，并术前测量了总前列腺特异性抗原，游离前列腺特异性抗原，[-2] proPSA，计算出的％freePSA和前列腺健康指数。格里森评分是在活检期间和根治性前列腺切除术后确定的。使用格里森评分，我们将患者分为2个亚组：格里森评分≤6和格里森评分> 6。根据活检格里森评分和术后格里森评分进行该划分。我们在活检后的Gleason评分≤6和Gleason评分> 6的亚组中比较了总前列腺特异性抗原，[-2] proPSA，％freePSA和前列腺健康指数，以及明确的评分。在评估由Gleason评分≤6和Gleason评分> 6创建的亚组时，我们仅在45.3％的病例中观察到活检Gleason评分与确定性Gleason评分之间的一致性。在计算的活检中，Gleason评分≤6和Gleason评分> 6个亚组，[-2] proPSA和前列腺健康指数（P = .0003和P = .0005）具有统计学意义。在确定的Gleason评分≤6和Gleason评分> 6个亚组中，前列腺健康指数，[-2] proPSA，％freePSA和PSA（P P P = .0003，P = .0043）具有统计学意义。根据术后格里森评分建立亚组时，前列腺健康指数可达到曲线值下的最佳面积（0.7496）。前列腺健康指数是Gleason评分6肿瘤分类和促进前列腺癌患者管理的最佳测试指标。前列腺健康指数可以作为主动监测或前列腺癌根治术的指标。前列腺健康指数还可以简化是否进行保留神经的前列腺癌根治术的决策。

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