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首页> 外文期刊>Taiwanese journal of obstetrics and gynecology >Maternal pregnancy-induced hypertension increases the subsequent risk of neonatal candidiasis: A nationwide population-based cohort study
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Maternal pregnancy-induced hypertension increases the subsequent risk of neonatal candidiasis: A nationwide population-based cohort study

机译：一项基于人口的全国性队列研究表明，孕产妇妊高症会增加随后发生新生儿念珠菌病的风险

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ObjectiveNeonatal candidiasis is a leading infectious cause of significant morbidity and mortality in premature birth mainly due to impaired physical barriers and immature immune system of fetus. Maternal pregnancy-induced hypertension (PIH) has been reported to be able to disturb the neonatal immune system, which could cause the increased possibility of neonatal infection. Therefore, we hypothesized that maternal PIH may increase the risk of neonatal candidiasis. The aim of this study was to evaluate whether PIH increased the risk of neonatal candidiasis and identify the predictive risk factors.Materials and methodsPatients with newly diagnosed PIH between January 1, 2000, and December 31, 2013 were selected from the Taiwan National Health Insurance Research Database (NHIRD). For each patient in the PIH cohort, 4 subjects without PIH, matched for age and year of delivery, were randomly selected as the comparison cohort. A Cox proportional regression model was used to estimate the risks of neonatal candidiasis in both cohorts.ResultsAmong the 23.3 million individuals registered in the NHIRD, 29,013 patients with PIH and 116,052 matched controls were identified. Patients with PIH had a higher incidence of neonatal candidiasis than did those without PIH. According to the multivariate analysis, PIH (odds ratio [OR]?=?2.08, 95% confidence interval [CI]?=?1.11–3.19,p?
机译：目的新生儿念珠菌病是导致早产的高发病率和高死亡率的主要传染病，其主要原因是胎儿的生理屏障受损和免疫系统不成熟。据报道，孕妇妊高征（PIH）能够干扰新生儿免疫系统，这可能导致新生儿感染的可能性增加。因此，我们假设母亲PIH可能会增加新生儿念珠菌病的风险。这项研究的目的是评估PIH是否会增加新生儿念珠菌病的风险并确定预测的危险因素。方法和方法从2000年1月1日至2013年12月31日期间从台湾国民健康保险研究中选出的新诊断为PIH的患者数据库（NHIRD）。对于PIH队列中的每位患者，随机选择4例年龄，分娩年限相匹配的无PIH的受试者作为比较队列。结果使用NHCRD登记的2330万人中，共鉴定了29,013例PIH患者和116,052例匹配的对照组，使用Cox比例回归模型评估了这两个队列中新生儿念珠菌病的风险。 PIH患者的新生儿念珠菌病发病率高于没有PIH的患者。根据多变量分析，PIH（赔率[OR]？=？2.08，95％置信区间[CI]？=？1.11-3.19，p？<？0.0228），单校验（OR？=？1.91，95％ CI≥1.00–3.65，p 0.0499）和早产（OR≥3.57，95％CI≥1.84-6.93，p = 0.0002）是新生儿发展的独立危险因素。结论具有PIH历史的患者与没有PIH的婴儿发生新生儿念珠菌病的风险增加有关。此外，早产是新生儿念珠菌病发展的独立危险因素。

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