• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The Application of Clinical Genetics >Chronic lymphocytic leukemia-associated chromosomal abnormalities and miRNA deregulation
【24h】

Chronic lymphocytic leukemia-associated chromosomal abnormalities and miRNA deregulation

机译：慢性淋巴细胞白血病相关的染色体异常和miRNA失调

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Abstract: Chronic lymphocytic leukemia is the most common leukemia in adults. By cytogenetic investigations major subgroups of the disease can be identified that reflect different routes of tumor development. Of these chromosomal deviations, trisomy 12 and deletions of parts of either the long arm of chromosome 13, the long arm of chromosome 11, or the short arm of chromosome 17 are most commonly detected. In some of these aberrations the molecular target has been identified as eg, ataxia telangiectasia mutated (ATM) in case of deletions of chromosomal region 11q22~23 and the genes encoding microRNAs miR-15a/16-1 as likely targets of deletions of chromosomal band 13q14.3. Of note, these aberrations do not characterize independent subgroups but often coexist within the metaphases of one tumor. Generally, complex aberrations are associated with a worse prognosis than simple karyotypic alterations. Due to smaller sizes of the missing segment the detection of recurrent deletions is not always possible by means of classical cytogenetics but requires more advanced techniques as in particular fluorescence in situ hybridization (FISH). Nevertheless, at this time it is not recommended to replace classical cytogenetics by FISH because this would miss additional information given by complex or secondary karyotypic alterations. However, the results of cytogenetic analyses allow the stratification of prognostic and predictive groups of the disease. Of these, the group characterized by deletions involving TP53 is clinically most relevant. In the future refined methods as eg, array-based comparative genomic hybridization will supplement the existing techniques to characterize CLL.
机译：摘要：慢性淋巴细胞性白血病是成人中最常见的白血病。通过细胞遗传学研究，可以确定该疾病的主要亚组，它们反映了肿瘤发展的不同途径。在这些染色体偏差中，最常检测到三体性12号和13号染色体长臂，11号染色体长臂或17号染色​​体短臂的部分缺失。在其中一些畸变中，分子目标已被鉴定为，例如，在染色体区域11q22〜23缺失的情况下，共济失调毛细血管扩张突变（ATM），而编码microRNA miR-15a / 16-1的基因可能是染色体条带缺失的目标13q14.3。值得注意的是，这些像差并不代表独立的亚组，而通常共存于一个肿瘤的中期。通常，与简单的核型改变相比，复杂的像差与更差的预后相关。由于缺失片段的大小较小，通过经典的细胞遗传学方法并不总是能够检测到重复缺失，但需要更先进的技术，尤其是荧光原位杂交（FISH）。但是，目前不建议用FISH代替经典的细胞遗传学，因为这会错过复杂或继发的核型改变所提供的其他信息。然而，细胞遗传学分析的结果允许对该疾病的预后和预测组进行分层。其中，以涉及TP53的缺失为特征的组在临床上最为相关。在将来，诸如基于阵列的比较基因组杂交的改进方法将补充现有技术以表征CLL。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号