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首页> 外文期刊>The British journal of psychiatry : >Schizotypal components in people at high risk of developing schizophrenia: early findings from the Edinburgh High-Risk Study
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Schizotypal components in people at high risk of developing schizophrenia: early findings from the Edinburgh High-Risk Study

机译：精神分裂症高发人群中的精神分裂症成分：爱丁堡高危研究的早期发现

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Background The study of high-risk groups and the development of schizophrenia. Aims To investigate further schizotypy, measured by the Structured Interview for Schizotypy (SIS), and to examine relationships between schizotypal components, psychotic symptoms on the Present State Examination (PSE) and subsequent schizophrenia. Method The SIS and PSE were administered on entry. Schizophrenia onsets were recorded during follow-up. Results The SIS yielded four principal components labelled social withdrawal, psychotic symptoms, socio-emotional dysfunction and odd behaviour. On entry, these differentiated between controls, subjects at risk for schizophrenia with and without symptoms and patients with schizophrenia. Seven of 78 subjects at risk developed schizophrenia within 39 months. This was best predicted by combining the four SIS components. Conclusions Schizotypy is heterogeneous and may become psychosis, particularly if several of its components are present. As psychosis develops, odd behaviour gives way to psychotic symptoms and social function deteriorates.
机译：背景研究高危人群和精神分裂症的发展。目的通过结构性访谈（SIS）对进一步的精神分裂症进行调查，以检查精神分裂症成分，当前状态检查中的精神病症状（PSE）与随后的精神分裂症之间的关系。方法SIS和PSE在进入时进行管理。在随访期间记录了精神分裂症发作。结果SIS产生了四个主要成分，分别是社交退缩，精神病症状，社会情感障碍和奇怪行为。入场时，这些在对照组，有症状和无症状的精神分裂症风险受试者以及精神分裂症患者之间有所区别。处于风险中的78位受试者中有7位在39个月内发展为精神分裂症。最好通过组合四个SIS组件来预测。结论精神分裂症是异质性的，可能会引起精神病，特别是如果存在其某些成分。随着精神病的发展，奇特的行为让位于精神病症状，社会功能恶化。

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