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首页> 外文期刊>The British journal of psychiatry : >Case—control study of neurocognitive function in euthymic patients with bipolar disorder: an association with mania
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Case—control study of neurocognitive function in euthymic patients with bipolar disorder: an association with mania

机译：双相情感障碍正常人的神经认知功能的病例对照研究：与躁狂症的关系

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Background Neurocognitive impairments in euthymic patients with bipolar disorder may represent trait rather than state variables. Aims To test the hypothesis that euthymic patients with bipolar disorder would exhibit impairment in verbal learning and memory and executive function compared with healthy controls matched for age, gender and premorbid IQ. Method Twenty euthymic patients with bipolar disorder were matched, on a case-by-case basis, to twenty healthy community controls. Cases and controls were tested with a battery of neuropsychological tests. Results Impairments were found in cases compared with controls in tests of verbal learning and memory. Verbal learning and memory correlated negatively with the number of manic episodes. Conclusions Impaired verbal learning and memory may be a trait variable in bipolar disease. There are implications for adherence to medication and relapse and for the role of early treatment interventions. Prospective designs and targeting first-episode groups may help to differentiate trait v . disease process effects.
机译：背景患有躁郁症的正常人患者的神经认知障碍可能代表特征而不是状态变量。目的为了检验假说，与年龄，性别和病前智商相匹配的健康对照组相比，躁郁症的正常人患者会表现出言语学习和记忆及执行功能障碍。方法将20例双相情感障碍的正常人正常患者与20例健康的社区对照患者进行配对。用一系列神经心理学测试对病例和对照进行测试。结果在语言学习和记忆测试中，与对照组相比，发现了障碍。言语学习和记忆与躁狂发作的次数呈负相关。结论言语学习和记忆障碍可能是双相情感障碍的特质变量。坚持药物治疗和复发以及早期治疗干预的作用都有影响。前瞻性设计和针对首批人群可能有助于区分特征v。疾病过程的影响。

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