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首页> 外文期刊>The British journal of psychiatry : >Examining the comorbidity of ADHD-related behaviours and conduct problems using a twin study design
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Examining the comorbidity of ADHD-related behaviours and conduct problems using a twin study design

机译：使用双胞胎研究设计检查与多动症相关行为和行为问题的合并症

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Background Although attention-deficit hyperactivity disorder (ADHD) and conduct disorder (CD) frequently co-occur, the underlying mechanisms for this comorbidity are not well understood. Aims To examine whether ADHD and conduct problems share common risk factors and whether ADHD+CD is a more heritable variant of ADHD. Method Questionnaires were sent to 2846 families. Parent-rated data were obtained for 2082 twin pairs and analysed using bivariate genetic analysis and a liability threshold model approach. Results The overlap of ADHD and conduct problems was explained by common genetic and non-shared environmental factors influencing both categories. Nevertheless, the two categories appeared to be partly distinct in that additional environmental factors influenced conduct problems. It appeared that ADHD+CD was a genetically more severe variant of ADHD. Conclusions Conduct problems and ADHD share a common genetic aetiology; ADHD+CD appears to be a more severe subtype in terms of genetic loading as well as clinical severity.
机译：背景技术尽管注意力缺陷多动障碍（ADHD）和行为障碍（CD）经常并发，但对于这种合并症的潜在机制尚不清楚。目的检查ADHD和行为问题是否具有共同的危险因素，以及ADHD + CD是否是ADHD的更遗传变异。方法将问卷调查表发送给2846个家庭。获得了2082对双亲的父母评价数据，并使用双变量遗传分析和责任阈值模型方法进行了分析。结果多动症和行为问题的重叠是由影响这两个类别的常见遗传因素和非共有环境因素引起的。然而，这两个类别似乎部分不同，因为其他环境因素影响了行为问题。看来ADHD + CD是ADHD的基因上更严重的变体。结论行为问题和多动症具有共同的遗传病因。就遗传负荷和临床严重性而言，ADHD + CD似乎是更严重的亚型。

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