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首页> 外文期刊>The British journal of psychiatry : >Recovery from psychotic illness: a 15- and 25-year international follow-up study
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Recovery from psychotic illness: a 15- and 25-year international follow-up study

机译：从精神病康复：一项为期15年和25年的国际随访研究

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Background Poorly defined cohorts and weak study designs have hampered cross-cultural comparisons of course and outcome in schizophrenia. Aims To describe long-term outcome in 18 diverse treated incidence and prevalence cohorts. To compare mortality, 15- and 25-year illness trajectory and the predictive strength of selected baseline and short-term course variables. Method Historic prospective study. Standardised assessments of course and outcome. Results About 75% traced. About 50% of surviving cases had favourable outcomes, but there was marked heterogeneity across geographic centres. In regression models, early (2-year) course patterns were the strongest predictor of 15-year outcome, but recovery varied by location; 16% of early unremitting cases achieved late-phase recovery. Conclusions A significant proportion of treated incident cases of schizophrenia achieve favourable long-term outcome. Sociocultural conditions appear to modify long-term course. Early intervention programmes focused on social as well as pharmacological treatments may realise longer-term gains.
机译：背景人群定义不清和研究设计薄弱阻碍了精神分裂症病程和结果的跨文化比较。目的描述18个不同治疗的发病率和患病率队列的长期结果。为了比较死亡率，15年和25年的疾病轨迹以及所选基线和短期病程变量的预测强度。方法历史前瞻性研究。课程和结果的标准化评估。结果追踪到大约75％。尚存的病例中约有50％的结果令人满意，但各个地理中心之间存在明显的异质性。在回归模型中，早期（2年）的课程模式是15年结局的最强预测指标，但恢复情况因地点而异。 16％的早期不懈病例实现了晚期恢复。结论相当一部分接受治疗的精神分裂症患者取得了良好的长期效果。社会文化条件似乎改变了长期课程。专注于社会及药物治疗的早期干预计划可能会取得长期收益。

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