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首页> 外文期刊>The British journal of psychiatry : >Impact of Pharmaceutical Impurities in Ecstasy Tablets: Gas Chromatography-Mass Spectrometry Study
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Impact of Pharmaceutical Impurities in Ecstasy Tablets: Gas Chromatography-Mass Spectrometry Study

机译：迷魂药片剂中药物杂质的影响：气相色谱-质谱法研究

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In this study, a simple and reliable method by gas chromatograph–mass spectrometry (GC–MS) was developed for the fast and regular identification of 3, 4-MDMA impurities in ecstasy tablets. In so doing, 8 samples of impurities were extracted by diethyl ether under alkaline condition and then analyzed by GC–MS. The results revealed high MDMA levels ranging from 37.6% to 57.7%. The GC-MS method showed that unambiguous identification can be achieved for MDMA from 3, 4-methylenedioxyamphetamine (MDA), Amphetamine (AM), methamphetamine (MA) and ketamine (Keta) compounds, respectively. The experimental results indicated the acceptable time window without interfering peaks. It is found that GC-MS was provided a suitable and rapid identification approach for MDMA (Ecstacy) tablets, particularly in the Forensic labs. Consequently, the intense MDMA levels would support the police to develop a simple quantification of impurity in Ecstasy tablets.
机译：在这项研究中，通过气相色谱-质谱法（GC-MS）开发了一种简单而可靠的方法，用于快速，常规地鉴定摇头丸中的3，4-MDMA杂质。这样，在碱性条件下用乙醚萃取了8个杂质样品，然后通过GC-MS分析。结果显示高MDMA水平范围从37.6％到57.7％。 GC-MS方法表明，可以分别由3、4-亚甲二氧基苯丙胺（MDA），苯丙胺（AM），甲基苯丙胺（MA）和氯胺酮（Keta）化合物对MDMA进行明确鉴定。实验结果表明可接受的时间窗口没有干扰峰。发现GC-MS为MDMA（迷魂药）片剂提供了一种合适的快速鉴定方法，尤其是在法医实验室中。因此，强烈的MDMA含量将支持警察对迷魂药片剂中的杂质进行简单定量。

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